An esterase-activated magnetic resonance contrast agent

被引：48
作者：
Giardiello, Marco
Lowe, Mark P.
Botta, Mauro
机构：
[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England
[2] Univ Piemonte Orientale, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 39期
关键词：
D O I：
10.1039/b711989e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.
引用
收藏
页码：4044 / 4046
页数：3
相关论文
共 37 条
  • [1] Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI
    Aime, S
    Gianolio, E
    Terreno, E
    Giovenzana, GB
    Pagliarin, R
    Sisti, M
    Palmisano, G
    Botta, M
    Lowe, MP
    Parker, D
    [J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2000, 5 (04): : 488 - 497
  • [2] High sensitivity lanthanide(III) based probes for MR-medical imaging
    Aime, S.
    Crich, S. Geninatti
    Gianolio, E.
    Giovenzana, G. B.
    Tei, L.
    Terreno, E.
    [J]. COORDINATION CHEMISTRY REVIEWS, 2006, 250 (11-12) : 1562 - 1579
  • [3] Dependence of the relaxivity and luminescence of gadolinium and europium amino-acid complexes on hydrogencarbonate and pH
    Aime, S
    Barge, A
    Botta, M
    Howard, JAK
    Kataky, R
    Lowe, MP
    Moloney, JM
    Parker, D
    de Sousa, AS
    [J]. CHEMICAL COMMUNICATIONS, 1999, (11) : 1047 - 1048
  • [4] Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations
    Aime, S
    Cabella, C
    Colombatto, S
    Crich, SG
    Gianolio, E
    Maggioni, F
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 2002, 16 (04) : 394 - 406
  • [5] A macromolecular Gd(III) complex as pH-responsive relaxometric probe for MRI applications
    Aime, S
    Botta, M
    Crich, SG
    Giovenzana, G
    Palmisano, G
    Sisti, M
    [J]. CHEMICAL COMMUNICATIONS, 1999, (16) : 1577 - 1578
  • [6] Non-radiative deactivation of the excited states of europium, terbium and ytterbium complexes by proximate energy-matched OH, NH and CH oscillators: an improved luminescence method for establishing solution hydration states
    Beeby, A
    Clarkson, IM
    Dickins, RS
    Faulkner, S
    Parker, D
    Royle, L
    de Sousa, AS
    Williams, JAG
    Woods, M
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1999, (03): : 493 - 503
  • [7] Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution:: An NMR relaxometric study
    Botta, M
    Aime, S
    Barge, A
    Bobba, G
    Dickins, RS
    Parker, D
    Terreno, E
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2003, 9 (09) : 2102 - 2109
  • [8] Lanthanides in magnetic resonance imaging
    Bottrill, Melanie
    Nicholas, Lilian Kwok
    Long, Nicholas J.
    [J]. CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) : 557 - 571
  • [9] The selectivity of reversible oxy-anion binding in aqueous solution at a chiral europium and terbium center: Signaling of carbonate chelation by changes in the form and circular polarization of luminescence emission
    Bruce, JI
    Dickins, RS
    Govenlock, LJ
    Gunnlaugsson, T
    Lopinski, S
    Lowe, MP
    Parker, D
    Peacock, RD
    Perry, JJB
    Aime, S
    Botta, M
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) : 9674 - 9684
  • [10] Stability constants and H-1 relaxation effects of ternary complexes formed between Gd-DTPA, Gd-DTPA-BMA, Gd-DOTA, and Gd-EDTA and citrate, phosphate, and carbonate ions
    Burai, L
    Hietapelto, V
    Kiraly, R
    Toth, E
    Brucher, E
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1997, 38 (01) : 146 - 150
1234