Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma

被引：6

作者：

Becker, Hannes ^{[1
,2
]}

Castaneda-Vega, Salvador ^{[3
,4
]}

Patzwaldt, Kristin ^{[3
]}

Przystal, Justyna M. ^{[1
,5
]}

Walter, Bianca ^{[1
]}

Michelotti, Filippo C. ^{[3
]}

Canjuga, Denis ^{[1
]}

Tatagiba, Marcos ^{[1
,2
]}

Pichler, Bernd ^{[4
,5
,6
]}

Beck, Susanne C. ^{[1
]}

Holland, Eric C. ^{[7
]}

la Fougere, Christian ^{[4
,5
,6
]}

Tabatabai, Ghazaleh ^{[1
,5
,6
]}

机构：

[1] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Comprehens Canc Ctr,Dept Neurol & Interdisciplina, Ctr Neurooncol,Hertie Inst Clin Brain Res, D-72072 Tubingen, Germany

[2] Eberhard Karls Univ Tubingen, Univ Hosp Tubingen, Dept Neurosurg, D-72072 Tubingen, Germany

[3] Eberhard Karls Univ Tuebingen, Werner Siemens Imaging Ctr, Dept Preclin Imaging & Radiopharm, D-72072 Tubingen, Germany

[4] Eberhard Karls Univ Tuebingen, Dept Nucl Med & Clin Mol Imaging, D-72072 Tubingen, Germany

[5] German Translat Canc Consortium DKTK, DKFZ Partner Site, D-72072 Tubingen, Germany

[6] Eberhard Karls Univ Tubingen, Cluster Excellence iFIT EXC 2180 Image Guided & F, D-72072 Tubingen, Germany

[7] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA

来源：

BRAIN SCIENCES | 2022年 / 12卷 / 11期

关键词：

glioblastoma; RCAS-tva; rodent glioma models; metabolism; multiparametric PET/MR imaging; model characterization; PDGFB; NEWLY-DIAGNOSED GLIOBLASTOMA; RANDOMIZED PHASE-III; ADJUVANT TEMOZOLOMIDE; MOUSE MODEL; SURVIVAL; MURINE; PET; RADIOTHERAPY; CANCER; CONCOMITANT;

D O I：

10.3390/brainsci12111426

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glioblastomas are incurable primary brain tumors harboring a heterogeneous landscape of genetic and metabolic alterations. Longitudinal imaging by MRI and [F-18]FET-PET measurements enable us to visualize the features of evolving tumors in a dynamic manner. Yet, close-meshed longitudinal imaging time points for characterizing temporal and spatial metabolic alterations during tumor evolution in patients is not feasible because patients usually present with already established tumors. The replication-competent avian sarcoma-leukosis virus (RCAS)/tumor virus receptor-A (tva) system is a powerful preclinical glioma model offering a high grade of spatial and temporal control of somatic gene delivery in vivo. Consequently, here, we aimed at using MRI and [F-18]FET-PET to identify typical neuroimaging characteristics of the platelet-derived growth factor B (PDGFB)-driven glioma model using the RCAS-tva system. Our study showed that this preclinical glioma model displays MRI and [F-18]FET-PET features that highly resemble the corresponding established human disease, emphasizing the high translational relevance of this experimental model. Furthermore, our investigations unravel exponential growth dynamics and a model-specific tumor microenvironment, as assessed by histology and immunochemistry. Taken together, our study provides further insights into this preclinical model and advocates for the imaging-stratified design of preclinical therapeutic interventions.

引用

页数：16

共 81 条

[1] Challenges to curing primary brain tumours [J].

Aldape, Kenneth ;

Brindle, Kevin M. ;

Chesler, Louis ;

Chopra, Rajesh ;

Gajjar, Amar ;

Gilbert, Mark R. ;

Gottardo, Nicholas ;

Gutmann, David H. ;

Hargrave, Darren ;

Holland, Eric C. ;

Jones, David T. W. ;

Joyce, Johanna A. ;

Kearns, Pamela ;

Kieran, Mark W. ;

Mellinghoff, Ingo K. ;

Merchant, Melinda ;

Pfister, Stefan M. ;

Pollard, Steven M. ;

Ramaswamy, Vijay ;

Rich, Jeremy N. ;

Robinson, Giles W. ;

Rowitch, David H. ;

Sampson, John H. ;

Taylor, Michael D. ;

Workman, Paul ;

Gilbertson, Richard J. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (08) :509-520

[2] AACR Project GENIE: Powering Precision Medicine through an International Consortium [J].

Andre, Fabrice ;

Arnedos, Monica ;

Baras, Alexander S. ;

Baselga, Jose ;

Bedard, Philippe L. ;

Berger, Michael F. ;

Bierkens, Mariska ;

Calvo, Fabien ;

Cerami, Ethan ;

Chakravarty, Debyani ;

Dang, Kristen K. ;

Davidson, Nancy E. ;

Del Vecchio, Fitz Catherine ;

Dogan, Semih ;

DuBois, Raymond N. ;

Ducar, Matthew D. ;

Futreal, P. Andrew ;

Gao Jianjiong ;

Garcia, Francisco ;

Gardos, Stu ;

Gocke, Christopher D. ;

Gross, Benjamin E. ;

Guinney, Justin ;

Heins, Zachary J. ;

Hintzen, Stephanie ;

Horlings, Hugo ;

Hudecek, Jan ;

Hyman, David M. ;

Kamel-Reid, Suzanne ;

Kandoth, Cyriac ;

Kinyua, Walter ;

Kumari, Priti ;

Kundra, Ritika ;

Ladanyi, Marc ;

Lefebvre, Celine ;

LeNoue-Newton, Michele L. ;

Lepisto, Eva M. ;

Levy, Mia A. ;

Lindeman, Neal, I ;

Lindsay, James ;

Liu, David ;

Lu Zhibin ;

MacConaill, Laura E. ;

Ian, Maurer ;

Maxwell, David S. ;

Meijer, Gerrit A. ;

Meric-Bernstam, Funda ;

Micheel, Christine M. ;

Miller, Clinton ;

Mills, Gordon .

CANCER DISCOVERY, 2017, 7 (08) :818-831

[3] Cancer models for reverse and forward translation [J].

不详 .

NATURE CANCER, 2022, 3 (02) :135-135

[4] Detection of immune responses after immunotherapy in glioblastoma using PET and MRI [J].

Antonios, Joseph P. ;

Soto, Horacio ;

Everson, Richard G. ;

Moughon, Diana L. ;

Wang, Anthony C. ;

Orpilla, Joey ;

Radu, Caius ;

Ellingson, Benjamin M. ;

Lee, Jason T. ;

Cloughesy, Timothy ;

Phelps, Michael E. ;

Czernin, Johannes ;

Liau, Linda M. ;

Prins, Robert M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (38) :10220-10225

[5] Does neoadjuvant anti-PD1 therapy improve glioblastoma outcome? [J].

Berghoff, Anna S. ;

Preusser, Matthias .

NATURE REVIEWS NEUROLOGY, 2019, 15 (06) :314-315

[6] Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma [J].

Berghoff, Anna Sophie ;

Kiesel, Barbara ;

Widhalm, Georg ;

Rajky, Orsolya ;

Ricken, Gerda ;

Woehrer, Adelheid ;

Dieckmann, Karin ;

Filipits, Martin ;

Brandstetter, Anita ;

Weller, Michael ;

Kurscheid, Sebastian ;

Hegi, Monika E. ;

Zielinski, Christoph C. ;

Marosi, Christine ;

Hainfellner, Johannes A. ;

Preusser, Matthias ;

Wick, Wolfgang .

NEURO-ONCOLOGY, 2015, 17 (08) :1064-1075

[7] Impact of 18F-FET PET/MRI on Clinical Management of Brain Tumor Patients [J].

Brendle, Cornelia ;

Maier, Caroline ;

Bender, Benjamin ;

Schittenhelm, Jens ;

Paulsen, Frank ;

Renovanz, Mirjam ;

Roder, Constantin ;

Castaneda-Vega, Salvador ;

Tabatabai, Ghazaleh ;

Ernemann, Ulrike ;

la Fougere, Christian .

JOURNAL OF NUCLEAR MEDICINE, 2022, 63 (04) :522-527

[8] The Somatic Genomic Landscape of Glioblastoma [J].

Brennan, Cameron W. ;

Verhaak, Roel G. W. ;

McKenna, Aaron ;

Campos, Benito ;

Noushmehr, Houtan ;

Salama, Sofie R. ;

Zheng, Siyuan ;

Chakravarty, Debyani ;

Sanborn, J. Zachary ;

Berman, Samuel H. ;

Beroukhim, Rameen ;

Bernard, Brady ;

Wu, Chang-Jiun ;

Genovese, Giannicola ;

Shmulevich, Ilya ;

Barnholtz-Sloan, Jill ;

Zou, Lihua ;

Vegesna, Rahulsimham ;

Shukla, Sachet A. ;

Ciriello, Giovanni ;

Yung, W. K. ;

Zhang, Wei ;

Sougnez, Carrie ;

Mikkelsen, Tom ;

Aldape, Kenneth ;

Bigner, Darell D. ;

Van Meir, Erwin G. ;

Prados, Michael ;

Sloan, Andrew ;

Black, Keith L. ;

Eschbacher, Jennifer ;

Finocchiaro, Gaetano ;

Friedman, William ;

Andrews, David W. ;

Guha, Abhijit ;

Iacocca, Mary ;

O'Neill, Brian P. ;

Foltz, Greg ;

Myers, Jerome ;

Weisenberger, Daniel J. ;

Penny, Robert ;

Kucherlapati, Raju ;

Perou, Charles M. ;

Hayes, D. Neil ;

Gibbs, Richard ;

Marra, Marco ;

Mills, Gordon B. ;

Lander, Eric ;

Spellman, Paul ;

Wilson, Richard .

CELL, 2013, 155 (02) :462-477

[9] Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate [J].

Bunse, Lukas ;

Pusch, Stefan ;

Bunse, Theresa ;

Sahm, Felix ;

Sanghvi, Khwab ;

Friedrich, Mirco ;

Alansary, Dalia ;

Sonner, Jana K. ;

Green, Edward ;

Deumelandt, Katrin ;

Kilian, Michael ;

Neftel, Cyril ;

Uhlig, Stefanie ;

Kessler, Tobias ;

von Landenberg, Anna ;

Berghoff, Anna S. ;

Marsh, Kelly ;

Steadman, Mya ;

Zhu, Dongwei ;

Nicolay, Brandon ;

Wiestler, Benedikt ;

Breckwoldt, Michael O. ;

Al-Ali, Ruslan ;

Karcher-Bausch, Simone ;

Bozza, Matthias ;

Oezen, Iris ;

Kramer, Magdalena ;

Meyer, Jochen ;

Habel, Antje ;

Eisel, Jessica ;

Poschet, Gernot ;

Weller, Michael ;

Preusser, Matthias ;

Nadji-Ohl, Minou ;

Thon, Niklas ;

Burger, Michael C. ;

Harter, Patrick N. ;

Ratliff, Miriam ;

Harbottle, Richard ;

Benner, Axel ;

Schrimpf, Daniel ;

Okun, Jurgen ;

Herold-Mende, Christel ;

Turcan, Sevin ;

Kaulfuss, Stefan ;

Hess-Stumpp, Holger ;

Bieback, Karen ;

Cahill, Daniel P. ;

Plate, Karl H. ;

Haenggi, Daniel .

NATURE MEDICINE, 2018, 24 (08) :1192-+

[10]

Chinot OL, 2014, NEW ENGL J MED, V370, P709, DOI 10.1056/NEJMoa1308345

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