Predicting Progression to Mild Cognitive Impairment

被引：35

作者：

Petersen, Ronald C. ^{[1
,2
]}

Lundt, Emily S. ^{[2
]}

Therneau, Terry M. ^{[2
]}

Weigand, Stephen D. ^{[2
]}

Knopman, David S. ^{[1
]}

Mielke, Michelle M. ^{[2
]}

Roberts, Rosebud O. ^{[2
]}

Lowe, Val J. ^{[3
]}

Machulda, Mary M. ^{[4
]}

Kremers, Walter K. ^{[2
]}

Geda, Yonas E. ^{[5
]}

Jack, Clifford R., Jr. ^{[3
]}

机构：

[1] Mayo Clin, Dept Neurol, 200 1st St SW, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin, Dept Radiol, Rochester, MN USA

[4] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA

[5] Mayo Clin, Dept Psychiat & Psychol, Phoenix, AZ USA

来源：

ANNALS OF NEUROLOGY | 2019年 / 85卷 / 01期

关键词：

ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DISEASE PATHOPHYSIOLOGY; RECOMMENDATIONS; DEMENTIA; MCI;

D O I：

10.1002/ana.25388

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is ANN NEUROL 2019;85:155-160.

引用

页码：155 / 160

页数：6

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