RETRACTED: The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target

被引：59
作者：
Chanda, Dipanjan [1 ,2 ]
Neumann, Dietbert [1 ,3 ]
Glatz, Jan F. C. [1 ]
机构：
[1] Maastricht Univ, Fac Hlth Med & Life Sci FHML, Dept Genet & Cell Biol, Maastricht, Netherlands
[2] Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea
[3] MUMC, CARIM, Dept Pathol, Maastricht, Netherlands
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2019年 / 140卷
关键词：
2-arachidonoylglyerol; Anandamide; Insulin resistance; Ccardiovascular disease; CB2 CANNABINOID RECEPTORS; PHARMACOLOGICAL STRATEGIES; SPECIES-DIFFERENCES; RISK-FACTORS; RIMONABANT; PAIN; IDENTIFICATION; HYPOTHALAMUS; MODULATION; OVERWEIGHT;
D O I：
10.1016/j.plefa.2018.11.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.
引用
收藏
页码：51 / 56
页数：6
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