Simulation study to improve the performance of a whole-body PbF2 Cherenkov TOF-PET scanner

被引：13

作者：

Consuegra, Dania ^{[1
]}

Korpar, Samo ^{[1
,2
]}

Krizan, Peter ^{[1
,3
]}

Pestotnik, Rok ^{[1
]}

Razdevsek, Gasper ^{[3
]}

Dolenec, Rok ^{[1
,3
]}

机构：

[1] Jozef Stefan Inst, Ljubljana, Slovenia

[2] Univ Maribor, Fac Chem & Chem Engn, Maribor, Slovenia

[3] Univ Ljubljana, Fac Math & Phys, Ljubljana, Slovenia

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2020年 / 65卷 / 05期

关键词：

positron emission tomography; Cherenkov radiation; lead fluoride; silicon photomultipliers; multi-layer detector; TIME-OF-FLIGHT; EMISSION; RECONSTRUCTION; SCINTILLATORS;

D O I：

10.1088/1361-6560/ab6f97

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Using Cherenkov radiation in positron emission tomography (PET) has the potential to improve the time of flight (TOF) resolution and reduce the cost of detectors. In previous studies promising TOF results were achieved when lead fluoride (PbF2) crystals were used instead of a scintillator. In this work, a whole-body PbF2 Cherenkov TOF-PET scanner was simulated and optimized. Different configurations of the PbF2 crystals and their surface treatment were considered. Also evaluated was the influence of the crystal-photodetector coupling and of the detection efficiency of the photodetectors. Of special interest is a whole-body PbF2 Cherenkov TOF-PET scanner with a multi-layer detector, which improves the time resolution and reduces the parallax error, without compromising the detection efficiency. Images of a phantom were reconstructed for different configurations of the simulated whole-body PbF2 Cherenkov TOF-PET scanner and the quality of images was compared to that of a whole-body TOF-PET scanner with standard LSO scintillators. The TOF resolution of the whole-body PbF2 Cherenkov TOF-PET scanner with a multi-layer detector was 143 ps FWHM, out of which the fundamental limitation due to light production and transportation was only 22 ps FWHM.

引用

页数：12

共 24 条

[1] Recent developments in GEANT4 [J].

Allison, J. ;

Amako, K. ;

Apostolakis, J. ;

Arce, P. ;

Asai, M. ;

Aso, T. ;

Bagli, E. ;

Bagulya, A. ;

Banerjee, S. ;

Barrand, G. ;

Beck, B. R. ;

Bogdanov, A. G. ;

Brandt, D. ;

Brown, J. M. C. ;

Burkhardt, H. ;

Canal, Ph. ;

Cano-Ott, D. ;

Chauvie, S. ;

Cho, K. ;

Cirrone, G. A. P. ;

Cooperman, G. ;

Cortes-Giraldo, M. A. ;

Cosmo, G. ;

Cuttone, G. ;

Depaola, G. ;

Desorgher, L. ;

Dong, X. ;

Dotti, A. ;

Elvira, V. D. ;

Folger, G. ;

Francis, Z. ;

Galoyan, A. ;

Garnier, L. ;

Gayer, M. ;

Genser, K. L. ;

Grichine, V. M. ;

Guatelli, S. ;

Gueye, P. ;

Gumplinger, P. ;

Howard, A. S. ;

Hrivnacova, I. ;

Hwang, S. ;

Incerti, S. ;

Ivanchenko, A. ;

Ivanchenko, V. N. ;

Jones, F. W. ;

Jun, S. Y. ;

Kaitaniemi, P. ;

Karakatsanis, N. ;

Karamitrosi, M. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2016, 835 :186-225

[2] Simulation and optimization of the Cherenkov TOF whole-body PET scanner [J].

Alokhina, Marharyta ;

Canot, Clotilde ;

Bezshyyko, Oleg ;

Kadenko, Igor ;

Tauzin, Gerard ;

Yvon, Dominique ;

Sharyy, Viatcheslav .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2018, 912 :378-381

[3]

[Anonymous], 2019, SIEMENS BIOGRAPH VIS

[4]

[Anonymous], 2019, VEREOS DIGITAL PET C

[5]

[Anonymous], 2018, HAMAMATSU CATALOGUE

[6] First Human Imaging Studies with the EXPLORER Total-Body PET Scanner [J].

Badawi, Ramsey D. ;

Shi, Hongcheng ;

Hu, Pengcheng ;

Chen, Shuguang ;

Xu, Tianyi ;

Price, Patricia M. ;

Ding, Yu ;

Spencer, Benjamin A. ;

Nardo, Lorenzo ;

Liu, Weiping ;

Bao, Jun ;

Jones, Terry ;

Li, Hongdi ;

Cherry, Simon R. .

JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (03) :299-303

[7]

BUDINGER TF, 1983, J NUCL MED, V24, P73

[8]

Cherry S.R., 2012, Physics in Nuclear Medicine, Vfourth

[9] Total-Body PET: Maximizing Sensitivity to Create New Opportunities for Clinical Research and Patient Care [J].

Cherry, Simon R. ;

Jones, Terry ;

Karp, Joel S. ;

Qi, Jinyi ;

Moses, William W. ;

Badawi, Ramsey D. .

JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (01) :3-12

[10] Comparison of Fast Scintillators With TOF PET Potential [J].

Conti, Maurizio ;

Eriksson, Lars ;

Rothfuss, Harold ;

Melcher, Charles L. .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2009, 56 (03) :926-933

← 1 2 3 →