Current Applications of Gold Nanoparticles for Medical Imaging and as Treatment Agents for Managing Pancreatic Cancer

被引：31

作者：

Banstola, Asmita ^{[1
]}

Emami, Fakhrossadat ^{[2
]}

Jeong, Jee-Heon ^{[3
]}

Yook, Simmyung ^{[1
]}

机构：

[1] Keimyung Univ, Coll Pharm, Daegu 42601, South Korea

[2] Univ Tehran Med Sci, Coll Pharm, Tehran, Iran

[3] Yeungnam Univ, Coll Pharm, Gyongsan 38541, Gyeongbuk, South Korea

来源：

MACROMOLECULAR RESEARCH | 2018年 / 26卷 / 11期

关键词：

pancreatic cancer; gold nanoparticles; nanomedicine; theragnostic; molecular imaging; TUMOR MICROENVIRONMENT; PHOTOTHERMAL ABLATION; CONTRAST AGENTS; DELIVERY; THERAPY; BIOLOGY; SIZE; NANOTECHNOLOGY; CHEMOTHERAPY; GEMCITABINE;

D O I：

10.1007/s13233-018-6139-4

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Pancreatic cancer is an extremely heterogeneous, malignant disease with a complicated tumor microenvironment and a dismal prognosis. Extensive stroma surrounding the cancer and the sequestering of chemotherapeutic agents play dominant roles in tumor growth and metastasis and in suppressing the delivery of cytotoxic drugs to tumor cells. Currently, nanoscience is in the forefront of developments aimed at devising novel techniques to treat tumors. Gold nanoparticles (GNPs) are often used as potential imaging and therapeutic agents for cancers, since they offer: (1) Passive targeting because of better permeation and retention effects, (2) photothermal effects caused by efficient light-to-heat conversion, and (3) the potential to use simple gold-thiol bioconjugation chemistry to conjugate desired molecules for targeted drug delivery. Together, these benefits can increase the therapeutic success of GNPs when used in combination with conventional treatment strategies, such as surgery, chemotherapy, or radiotherapy. In this review, we discuss current trends in GNP research in the field of pancreatic cancer theranostics.

引用

页码：955 / 964

页数：10

共 122 条

[1] Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles [J].

Abadeer, Nardine S. ;

Murphy, Catherine J. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2016, 120 (09) :4691-4716

[2] Biosynthesis and characterization of gold nanoparticles: Kinetics, in vitro and in vivo study [J].

Ahmad, Nabeel ;

Bhatnagar, Sharad ;

Saxena, Ritika ;

Iqbal, Danish ;

Ghosh, A. K. ;

Dutta, Rajiv .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 78 :553-564

[3] Theranostic applications of nanoparticles in cancer [J].

Ahmed, Naveed ;

Fessi, Hatem ;

Elaissari, Abdelhamid .

DRUG DISCOVERY TODAY, 2012, 17 (17-18) :928-934

[4] Molecular characterization of the tumor microenvironment in breast cancer [J].

Allinen, M ;

Beroukhim, R ;

Cai, L ;

Brennan, C ;

Lahti-Domenici, J ;

Huang, HY ;

Porter, D ;

Hu, M ;

Chin, L ;

Richardson, A ;

Schnitt, S ;

Sellers, WR ;

Polyak, K .

CANCER CELL, 2004, 6 (01) :17-32

[5] Copper-64 Radiopharmaceuticals for PET Imaging of Cancer: Advances in Preclinical and Clinical Research [J].

Anderson, Carolyn J. ;

Ferdani, Riccardo .

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2009, 24 (04) :379-393

[6]

[Anonymous], 2016, J NANOMATERIALS

[7]

[Anonymous], 2011, ACTA NATURAE

[8]

[Anonymous], NUCL ONCOLOGY PATHOP

[9]

[Anonymous], INT J RAD BIOL

[10]

[Anonymous], INT J PHARM INVESTIG

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