Uncovering the Mechanisms of Shrimp Innate Immune Response by RNA Interference

被引:30
作者
Hirono, Ikuo [1 ]
Fagutao, Fernand F. [1 ]
Kondo, Hidehiro [1 ]
Aoki, Takashi [1 ]
机构
[1] Tokyo Univ Marine Sci & Technol, Lab Genome Sci, Grad Sch Marine Sci & Technol, Minato Ku, Tokyo 1088477, Japan
关键词
Shrimp; RNAi; Innate immunity; BLACK TIGER SHRIMP; SPOT-SYNDROME-VIRUS; FRESH-WATER CRAYFISH; DOUBLE-STRANDED-RNA; PROPHENOLOXIDASE-ACTIVATING SYSTEM; PLASMA CLOTTING PROTEIN; PENAEUS-MONODON; LITOPENAEUS-VANNAMEI; MOLECULAR-CLONING; ANTILIPOPOLYSACCHARIDE FACTOR;
D O I
10.1007/s10126-010-9292-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Because of the importance of shrimp in world aquaculture, there is much interest in understanding their immune system in order to improve their resistance to pathogenic microorganisms. An effective tool in studying genes involved in the immune response in shrimp is RNA interference (RNAi). RNAi, first recognized as an antiviral response against RNA viruses, is a cellular mechanism that is triggered by double-stranded RNAs and results in the degradation of homologous genes. In this review, we describe the current studies of genes in shrimp that employed RNAi technology to elucidate or confirm their functions. We also review the potential of RNAi to elicit antiviral response in shrimp.
引用
收藏
页码:622 / 628
页数:7
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