Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities

被引：30
作者：
Mossello, Enrico [1 ]
Ballini, Elena
Boncinelli, Marta
Lonetto, Giuseppe
Mello, Anna Maria
Tarantini, Francesca
Baldasseroni, Samuele
Mannucci, Edoardo
Marchionni, Niccolo
机构：
[1] Univ Florence, Unit Gerontol & Geriatr Med, Dept Crit Care Med & Surg, I-50121 Florence, Italy
来源：
EXPERIMENTAL DIABETES RESEARCH | 2011年
关键词：
CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE SYNDROME; ALZHEIMERS-DISEASE; BRAIN; BETA; GLUCOSE; MELLITUS; ASSOCIATION; POPULATION; ROTTERDAM;
D O I：
10.1155/2011/281674
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration. Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline.
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页数：6
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