A short helix in the C-terminal region of LolA is important for the specific membrane localization of lipoproteins

被引：24

作者：

Okuda, Suguru ^{[1
]}

Watanabe, Shoji ^{[1
]}

Tokuda, Hajime ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

FEBS LETTERS | 2008年 / 582卷 / 15期

关键词：

lipoprotein; molecular chaperone; outer membrane; periplasm; LolA; Escherichia coli;

D O I：

10.1016/j.febslet.2008.05.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structures of a lipoprotein carrier, LolA, and a lipoprotein receptor, LolB, are similar except for an extra C-terminal loop containing a 3(10) helix and beta-strand 12 in LolA. Lipoprotein release was significantly reduced when beta-12 was deleted. Deletion of the 3(10) helix also inhibited the lipoprotein release. Furthermore, lipoproteins were non-specifically localized to membranes when LolA lacked the 3(10) helix. Thus, the membrane localization of lipoproteins with the LolA derivative lacking the 3(10) helix was independent of LolB whereas LolB was essential for the outer membrane localization of lipoproteins with the wild-type LolA. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2247 / 2251

页数：5

共 50 条

[31] DNA Clasping by Mycobacterial HU: The C-Terminal Region of HupB Mediates Increased Specificity of DNA Binding
Kumar, Sandeep
Sardesai, Abhijit A.
Basu, Debashree
Muniyappa, Kalappagowda
Hasnain, Seyed E.
PLOS ONE, 2010, 5 (09): : 1 - 10
[32] The HydS C-terminal domain of the Thiocapsa bogorovii HydSL hydrogenase is involved in membrane anchoring and electron transfer
Khasimov, Makhmadyusuf K.
Petushkova, Ekaterina P.
Khusnutdinova, Anna N.
Zorin, Nikolay A.
Batyrova, Khorcheska A.
Yakunin, Alexander F.
Tsygankov, Anatoly A.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2021, 1862 (12):
[33] C-terminal truncation of a Tat passenger protein affects its membrane translocation by interfering with receptor binding
Schlesier, Rene
Kloesgen, Ralf Bernd
BIOLOGICAL CHEMISTRY, 2015, 396 (04) : 349 - 357
[34] Bacterial expression and characterization of an active recombinant lipase A from Serratia marcescens with truncated C-terminal region
Mohammadi, Mohsen
Sepehrizadeh, Zargham
Ebrahim-Habibi, Azadeh
Shahverdi, Ahmad Reza
Faramarzi, Mohammad Ali
Setayesh, Neda
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2015, 120 : 84 - 92
[35] The C-terminal Helix of Pseudomonas aeruginosa Elongation Factor Ts Tunes EF-Tu Dynamics to Modulate Nucleotide Exchange
De Laurentiis, Evelina Ines
Mercier, Evan
Wieden, Hans-Joachim
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (44) : 23136 - 23148
[36] Amputation of a C-terminal helix of the γ subunit increases ATP-hydrolysis activity of cyanobacterial F1 ATP synthase
Kondo, Kumiko
Takeyama, Yu
Sunamura, Ei-ichiro
Madoka, Yuka
Fukaya, Yuki
Isu, Atsuko
Hisabori, Toru
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2018, 1859 (05): : 319 - 325
[37] Peptidoglycan-associated outer membrane protein Mep45 of rumen anaerobe Selenomonas ruminantium forms a non-specific diffusion pore via its C-terminal transmembrane domain
Kojima, Seiji
Hayashi, Kanako
Tochigi, Saeko
Kusano, Tomonobu
Kaneko, Jun
Kamio, Yoshiyuki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2016, 80 (10) : 1954 - 1959
[38] Plastid HSP90C C-terminal extension region plays a regulatory role in chaperone activity and client binding
Mu, Bona
Nair, Adheip Monikantan
Zhao, Rongmin
PLANT JOURNAL, 2024, 119 (05) : 2288 - 2302
[39] Biophysical characterization of the C-terminal region of FliG, an essential rotor component of the Na+-driven flagellar motor
Gohara, Mizuki
Kobayashi, Shiori
Abe-Yoshizumi, Rei
Nonoyama, Natsumi
Kojima, Seiji
Asami, Yasuo
Homma, Michio
JOURNAL OF BIOCHEMISTRY, 2014, 155 (02) : 83 - 89
[40] The Pro-Form of Stereum purpureum Endopolygalacturonase I Is Inactivated by a Pro-Sequence in the C-Terminal Region
Ogawa, Shun
Shimizu, Tetsuya
Kimura, Tsubasa
Utoh, Kazunori
Okuno, Toshikatsu
Miyairi, Kazuo
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2010, 74 (03) : 558 - 562

← 1 2 3 4 5 →