HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses

被引:28
|
作者
Schust, DJ [1 ]
Tortorella, D [1 ]
Ploegh, HL [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
关键词
antigen presentation; HLA-G; immunoevasion; trophoblast; virus;
D O I
10.1006/scbi.1998.0106
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Immunoevasive viruses which effect antigen presentation by class I major histocompatibility complex (MHC) molecules have helped to broaden our understanding of the intracellular transport and processing of HLA-G and HLA-C in the Placenta. Cellular infection with herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are each associated with the downregulation of surface expression of HLA-A and -B, albeit by remarkably distinct mechanisms. Investigations on the effects of HSV and HCMV infection on HLA-G and HLA-C in the trophoblast have revealed both hypothesized similarities and surprising differences between trophoblast and classical class I products.
引用
收藏
页码:37 / 46
页数:10
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