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Are Isofurans and Neuroprostanes Increased After Subarachnoid Hemorrhage and Traumatic Brain Injury?
被引:34
作者:
Corcoran, Tomas B.
[3
]
Mas, Emilie
[1
,2
]
Barden, Anne E.
[1
,2
]
Durand, Thierry
[4
]
Galano, Jean-Marie
[4
]
Roberts, L. Jackson, II
[5
]
Phillips, Michael
[6
]
Ho, Kwok M.
[7
]
Mori, Trevor A.
[1
,2
]
机构:
[1] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia
[2] Cardiovasc Res Ctr, Perth, WA, Australia
[3] Royal Perth Hosp, Dept Anaesthesia & Pain Med, Perth, WA, Australia
[4] Inst Biomol Max Mousseron IBMM UMR 5247 CNRS UM 1, Fac Pharm, Montpellier, France
[5] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA
[6] Univ Western Australia, Western Australian Inst Med Res, Perth, WA 6847, Australia
[7] Univ Western Australia, Sch Populat Hlth, Perth, WA 6847, Australia
基金:
美国国家卫生研究院;
关键词:
CEREBROSPINAL-FLUID;
LIPID-PEROXIDATION;
OXIDATIVE STRESS;
CHILDREN;
MARKERS;
INFANTS;
D O I:
10.1089/ars.2011.4125
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Current diagnostic tools to assess neurological injury after aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI) have poor discriminatory abilities. Free radicals are associated with the pathophysiology of secondary damage after brain trauma. We examined cerebrospinal fluid (CSF) lipid markers of oxidative stress, isofurans (IsoFs), F(4)-neuroprostanes (F(4)-NeuroPs), and F(2)-isoprostanes (F(2)-IsoPs), in two case-controlled studies in patients with aSAH or severe TBI. Patients with aSAH (n = 18) or TBI (n = 18) were age and gender matched with separate control groups. CSF samples were collected from patients within 24 h of the injury. CSF IsoFs and F(4)-NeuroPs were increased in aSAH patients compared with their controls. In TBI patients, IsoFs and F(4)-NeuroPs were increased compared with their controls. F(2)-IsoPs were increased in aSAH patients, but not in TBI patients, compared with their respective controls. CSF IsoFs and F(4)-NeuroPs are consistently increased after a catastrophic central nervous system injury. These results suggest their measurement may enhance the management of unconscious patients in neurological care. Antioxid. Redox Signal. 15, 2663-2667.
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页码:2663 / 2667
页数:5
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