Map-based model of the cardiac action potential

被引:5
|
作者
Pavlov, Evgeny A. [1 ]
Osipov, Grigory V. [1 ]
Chan, C. K. [2 ]
Suykens, Johan A. K. [3 ]
机构
[1] Nizhnii Novgorod State Univ, Dept Computat Math & Cybernet, Nizhnii Novgorod 603950, Russia
[2] Acad Sinica, Inst Phys, Taipei 115, Taiwan
[3] Katholieke Univ Leuven, ESAT SCD SISTA, B-3001 Heverlee, Belgium
关键词
Mathematical modeling; Excitable and oscillatory dynamics; Synchronization; Spiral waves; TISSUE MODEL; MYOCYTES; DYNAMICS; MUSCLE;
D O I
10.1016/j.physleta.2011.06.014
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
A simple computationally efficient model which is capable of replicating the basic features of cardiac cell action potential is proposed. The model is a four-dimensional map and demonstrates good correspondence with real cardiac cells. Various regimes of cardiac activity, which can be reproduced by the proposed model, are shown. Bifurcation mechanisms of these regimes transitions are explained using phase space analysis. The dynamics of 1D and 2D lattices of coupled maps which model the behavior of electrically connected cells is discussed in the context of synchronization theory. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:2894 / 2902
页数:9
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