Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy

被引：463
作者：
Ding, Dah-Ching [1 ,2 ]
Chang, Yu-Hsun [2 ,3 ]
Shyu, Woei-Cherng [4 ,5 ]
Lin, Shinn-Zong [4 ,5 ,6 ]
机构：
[1] Tzu Chi Univ, Buddhist Tzu Chi Gen Hosp, Dept Obstet & Gynecol, Hualien, Taiwan
[2] Tzu Chi Univ, Grad Inst Med Sci, Hualien, Taiwan
[3] Tzu Chi Univ, Buddhist Tzu Chi Gen Hosp, Dept Pediat, Hualien, Taiwan
[4] China Med Univ & Hosp, Ctr Neuropsychiat, Taichung, Taiwan
[5] China Med Univ, Grad Inst Immunol, Taichung, Taiwan
[6] China Med Univ, Beigang Hosp, Yunlin, Taiwan
来源：
CELL TRANSPLANTATION | 2015年 / 24卷 / 03期
关键词：
Umbilical cord; Wharton's jelly; Clinical application; Stem cells; STROMAL CELLS; IMMUNOSUPPRESSIVE PROPERTIES; GENE-THERAPY; IN-VITRO; CONDITIONED MEDIUM; LINING MEMBRANE; LIVER FIBROSIS; STROKE MODEL; BONE-MARROW; GROWTH;
D O I：
10.3727/096368915X686841
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs). Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster self-renewal properties. Different derivation protocols may provide different amounts and populations of stem cells. Stem cell populations have also been reported in other compartments of the umbilical cord, such as the cord lining, perivascular tissue, and Wharton's jelly. HUCMSCs are noncontroversial sources compared to embryonic stem cells. They can differentiate into the three germ layers that promote tissue repair and modulate immune responses and anticancer properties. Thus, they are attractive autologous or allogenic agents for the treatment of malignant and nonmalignant solid and soft cancers. HUCMCs also can be the feeder layer for embryonic stem cells or other pluripotent stem cells. Regarding their therapeutic value, storage banking system and protocols should be established immediately.
引用
收藏
页码：339 / 347
页数：9
相关论文
共 77 条
[1]   Naive human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo [J].
Ayuzawa, Rie ;
Doi, Chiyo ;
Rachakatla, Raja Shekar ;
Pyle, Marla M. ;
Maurya, Dharmendra Kumar ;
Troyer, Deryl ;
Tamura, Masaaki .
CANCER LETTERS, 2009, 280 (01) :31-37
[2]   Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells [J].
Campard, David ;
Lysy, Philippe A. ;
Najimi, Mustapha ;
Sokal, E-Fienne Marc .
GASTROENTEROLOGY, 2008, 134 (03) :833-848
[3]   Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia [J].
Cavazzana-Calvo, Marina ;
Payen, Emmanuel ;
Negre, Olivier ;
Wang, Gary ;
Hehir, Kathleen ;
Fusil, Floriane ;
Down, Julian ;
Denaro, Maria ;
Brady, Troy ;
Westerman, Karen ;
Cavallesco, Resy ;
Gillet-Legrand, Beatrix ;
Caccavelli, Laure ;
Sgarra, Riccardo ;
Maouche-Chretien, Leila ;
Bernaudin, Francoise ;
Girot, Robert ;
Dorazio, Ronald ;
Mulder, Geert-Jan ;
Polack, Axel ;
Bank, Arthur ;
Soulier, Jean ;
Larghero, Jerome ;
Kabbara, Nabil ;
Dalle, Bruno ;
Gourmel, Bernard ;
Socie, Gerard ;
Chretien, Stany ;
Cartier, Nathalie ;
Aubourg, Patrick ;
Fischer, Alain ;
Cornetta, Kenneth ;
Galacteros, Frederic ;
Beuzard, Yves ;
Gluckman, Eliane ;
Bushman, Frederick ;
Hacein-Bey-Abina, Salima ;
Leboulch, Philippe .
NATURE, 2010, 467 (7313) :318-U94
[4]   Placenta-derived multipotent cells exhibit immunosuppressive properties that are enhanced in the presence of interferon-γ [J].
Chang, Chun-Jung ;
Yen, Men-Luh ;
Chen, Yao-Chang ;
Chien, Chih-Cheng ;
Huang, Hsing-I. ;
Bai, Chyi-Huey ;
Yen, B. Linju .
STEM CELLS, 2006, 24 (11) :2466-2477
[5]   Human umbilical cord mesenchymal stem cells suppress breast cancer tumourigenesis through direct cell-cell contact and internalization [J].
Chao, Kuo-Ching ;
Yang, Hui-Tai ;
Chen, Min-Wei .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2012, 16 (08) :1803-1815
[6]   Optimizing isolation culture and freezing methods to preserve Wharton's jelly's mesenchymal stem cell (MSC) properties: an MSC banking protocol validation for the Hellenic Cord Blood Bank [J].
Chatzistamatiou, Theofanis K. ;
Papassavas, Andreas C. ;
Michalopoulos, Efstathios ;
Gamaloutsos, Christos ;
Mallis, Panagiotis ;
Gontika, Ioanna ;
Panagouli, Effrosyni ;
Koussoulakos, Stauros L. ;
Stavropoulos-Giokas, Catherine .
TRANSFUSION, 2014, 54 (12) :3108-3120
[7]   Human feeder layer system derived from umbilical cord stromal cells for human embryonic stem cells [J].
Cho, Meeyoung ;
Lee, Eun Ju ;
Nam, Hyun ;
Yang, Ji-Hye ;
Cho, Jaejin ;
Lim, Jeong Mook ;
Lee, Gene .
FERTILITY AND STERILITY, 2010, 93 (08) :2525-2531
[8]  
De Miguel MP, 2012, CURR MOL MED, V12, P574
[9]  
Ding D. C., 2014, CELL TRANSPLANT
[10]   Enhancement of neuroplasticity through upregulation of β1-integrin in human umbilical cord-derived stromal cell implanted stroke model [J].
Ding, Dah-Ching ;
Shyu, Woei-Cherng ;
Chiang, Ming-Fu ;
Lin, Shinn-Zong ;
Chang, Ying-Chen ;
Wang, Hslao-Jung ;
Su, Ching-Yuan ;
Li, Hung .
NEUROBIOLOGY OF DISEASE, 2007, 27 (03) :339-353
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