A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases

被引：98
作者：
He, Siqin [1 ,2 ]
Gui, Jiajia [1 ,2 ]
Xiong, Kun [1 ,2 ]
Chen, Meiwan [1 ,2 ]
Gao, Huile [1 ,2 ]
Fu, Yao [1 ,2 ]
机构：
[1] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China
来源：
JOURNAL OF NANOBIOTECHNOLOGY | 2022年 / 20卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Drug delivery; Lung; Pulmonary infectious disease; Targeting; Therapeutic strategies; AEROSOL DRUG-DELIVERY; PSEUDOMONAS-AERUGINOSA; PARTICLE DEPOSITION; ANTIBIOTIC SUSCEPTIBILITY; HAEMOPHILUS-INFLUENZAE; NANOPARTICLE DIFFUSION; ALVEOLAR MACROPHAGES; INHALATION-THERAPY; BIOFILM FORMATION; ANIMAL-MODELS;
D O I：
10.1186/s12951-022-01307-x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view.
引用
收藏
页数：22
相关论文
共 185 条
[1]   Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections [J].
Agarwal, Rachit ;
Johnson, Christopher T. ;
Imhoff, Barry R. ;
Donlan, Rodney M. ;
McCarty, Nael A. ;
Garcia, Andres J. .
NATURE BIOMEDICAL ENGINEERING, 2018, 2 (11) :841-849
[2]  
Agu RU, 2001, RESP RES, V2, P198
[3]   International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia [J].
Aliberti, Stefano ;
Cook, Grayden S. ;
Babu, Bettina L. ;
Reyes, Luis F. ;
Rodriguez, Alejandro H. ;
Sanz, Francisco ;
Soni, Nilam J. ;
Anzueto, Antonio ;
Faverio, Paola ;
Sadud, Ricardo Franco ;
Muhammad, Irfan ;
Prat, Cristina ;
Vendrell, Ester ;
Neves, Joao ;
Kaimakamis, Evangelos ;
Feneley, Andrew ;
Swarnakar, Rajesh ;
Franzetti, Fabio ;
Carugati, Manuela ;
Morosi, Manuela ;
Monge, Elisa ;
Restrepo, Marcos, I ;
Karina Aruj, Patricia ;
Attorri, Silvia ;
Barimboim, Enrique ;
Pablo Caeiro, Juan ;
Garzon, Maria, I ;
Hugo Cambursano, Victor ;
Ceccato, Adrian ;
Chertcoff, Julio ;
Lascar, Florencia ;
Di Tulio, Fernando ;
Cordon Diaz, Ariel ;
de Vedia, Lautaro ;
Cristina Ganaha, Maria ;
Lambert, Sandra ;
Lopardo, Gustavo ;
Lopez, Vicente ;
Luna, Carlos M. ;
Gerardo Malberti, Alessio ;
Morcillo, Nora ;
Tartara, Silvina ;
Pensotti, Claudia ;
Pereyra, Betiana ;
Gustavo Scapellato, Pablo ;
Pablo Stagnaro, Juan ;
Shah, Sonali ;
Lotsch, Felix ;
Thalhammer, Florian ;
Anseeuw, Kurt .
JOURNAL OF INFECTION, 2019, 79 (04) :300-311
[4]   Chemical modification of drug molecules as strategy to reduce interactions with mucus [J].
Araujo, Francisca ;
Martins, Claudia ;
Azevedo, Claudia ;
Sarmento, Bruno .
ADVANCED DRUG DELIVERY REVIEWS, 2018, 124 :98-106
[5]   NanoCipro encapsulation in monodisperse large porous PLGA microparticles [J].
Arnold, Matthew M. ;
Gonnan, Enic M. ;
Schieber, Loren J. ;
Munson, Eric J. ;
Berkland, Cory .
JOURNAL OF CONTROLLED RELEASE, 2007, 121 (1-2) :100-109
[6]   Macrophages: Their role, activation and polarization in pulmonary diseases [J].
Arora, Shweta ;
Dev, Kapil ;
Agarwal, Beamon ;
Das, Pragnya ;
Syed, Mansoor Ali .
IMMUNOBIOLOGY, 2018, 223 (4-5) :383-396
[7]   Capturing the Onset of Bacterial Pulmonary Infection in Acini-On-Chips [J].
Artzy-Schnirman, Arbel ;
Zidan, Hikaia ;
Elias-Kirma, Shani ;
Ben-Porat, Lee ;
Tenenbaum-Katan, Janna ;
Carius, Patrick ;
Fishler, Ramy ;
Schneider-Daum, Nicole ;
Lehr, Claus-Michael ;
Sznitman, Josue .
ADVANCED BIOSYSTEMS, 2019, 3 (09)
[8]   Central nervous system manifestations of COVID-19: A systematic review [J].
Asadi-Pooya, Ali A. ;
Simani, Leila .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2020, 413
[9]   Prediction of particle deposition in the human lung using realistic models of lung ventilation [J].
Asgharian, B. ;
Price, O. T. ;
Hofmann, W. .
JOURNAL OF AEROSOL SCIENCE, 2006, 37 (10) :1209-1221
[10]   Nanotechnology-Based Targeted Drug Delivery: An Emerging Tool to Overcome Tuberculosis [J].
Baranyai, Zsuzsa ;
Soria-Carrera, Hector ;
Alleva, Maria ;
Millan-Placer, Ana C. ;
Lucia, Ainhoa ;
Martin-Rapun, Rafael ;
Ainsa, Jose A. ;
de la Fuente, Jesus M. .
ADVANCED THERAPEUTICS, 2021, 4 (01)
12345678910