Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

被引：80

作者：

Anahi Valdes-Rives, Silvia ^{[1
]}

Casique-Aguirre, Diana ^{[2
]}

German-Castelan, Liliana ^{[1
]}

Velasco-Velazquez, Marco A. ^{[2
,3
]}

Gonzalez-Arenas, Aliesha ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dep Med Genom & Toxicol Ambiental, Ciudad De Mexico, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Ciudad De Mexico, Mexico

[3] Univ Nacl Autonoma Mexico, Fac Med, Unidad Perifer Invest Biomed Translac, ISSSTE CMN Noviembre 20, Ciudad De Mexico, Mexico

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

NF-KAPPA-B; GLIOMA STEM-CELLS; SMALL-MOLECULE INHIBITOR; X-LINKED INHIBITOR; BCL-2; FAMILY; GROWTH-FACTOR; PTEN GENE; FACTOR RECEPTOR; EXPRESSION; MULTIFORME;

D O I：

10.1155/2017/7403747

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.

引用

页数：12

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