Apolipoprotein E regulatory region genotype in schizophrenia

被引：7

作者：

Shinkai, T ^{[1
]}

Ohmori, O ^{[1
]}

Kojima, H ^{[1
]}

Terao, T ^{[1
]}

Suzuki, T ^{[1
]}

Abe, K ^{[1
]}

Nakamura, J ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 256卷 / 01期

关键词：

apolipoprotein E; schizophrenia; Alzheimer's disease; regulatory region; genetic polymorphism; chromosome; 19;

D O I：

10.1016/S0304-3940(98)00761-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Clinical observations indicate that a proportion of patients with schizophrenia experience cognitive impairment, which suggests that a neurodegenerative basis might be involved in the etiology of schizophrenia. Apolipoprotein E (ApoE), which has been confirmed to be genetically associated with Alzheimer's disease, is thus highlighted as a candidate gene for schizophrenia. Recently, novel functional polymorphisms in the ApoE transcriptional regulatory region have been found. To investigate whether these polymorphisms are associated with the risk of schizophrenia, we genotyped 144 patients with schizophrenia and 134 controls for two polymorphisms (-491A/T and -21SGTT). No significant positive associations between both polymorphisms and schizophrenia were observed. Our findings exclude the regulatory region of the ApoE gene as a locus that might confer increased susceptibility to schizophrenia. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：57 / 60

页数：4

共 20 条

[1] ELDERLY PATIENTS WITH SCHIZOPHRENIA EXHIBIT INFREQUENT NEURODEGENERATIVE LESIONS [J].