A Novel Respiratory Model of Infection with Monkeypox Virus in Cynomolgus Macaques

被引：63

作者：

Goff, Arthur J. ^{[1
]}

Chapman, Jennifer ^{[1
]}

Foster, Chad ^{[2
]}

Wlazlowski, Carly ^{[1
]}

Shamblin, Joshua ^{[1
]}

Lin, Kenny ^{[1
]}

Kreiselmeier, Norman ^{[3
]}

Mucker, Eric ^{[1
]}

Paragas, Jason ^{[4
]}

Lawler, James ^{[4
]}

Hensley, Lisa ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Frederick, MD USA

[2] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA

[3] Tripler Army Med Ctr, Honolulu, HI 96859 USA

[4] NIAID, Integrated Res Facil, NIH, Frederick, MD USA

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 10期

关键词：

SMALLPOX; CONGO; PATHOLOGY;

D O I：

10.1128/JVI.02525-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.

引用

页码：4898 / 4909

页数：12

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