Hypocretin and Its Emerging Role as a Target for Treatment of Sleep Disorders

被引：18

作者：

Cao, Michelle ^{[1
]}

Guilleminault, Christian ^{[1
]}

机构：

[1] Stanford Univ Sleep Med, Redwood City, CA 94063 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2011年 / 11卷 / 02期

关键词：

Hypocretin; Orexin; Narcolepsy; Cataplexy; Sleep; Wakefulness; Hypothalamus; Insomnia; Arousal; Almorexant; OREXIN-A; WAKING DISCHARGE; HUMAN NARCOLEPSY; BASAL FOREBRAIN; RAT-BRAIN; NEURONS; WAKEFULNESS; MICE; RECEPTOR; PEPTIDES;

D O I：

10.1007/s11910-010-0172-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neuropeptides hypocretin-1 and -2 (orexin A and B) are critical in the regulation of arousal and maintenance of wakefulness. Understanding the role of the hypocretin system in sleep/wake regulation has come from narcolepsy-cataplexy research. Deficiency of hypocretin results in loss of sleep/wake control with consequent unstable transitions from wakefulness into non-rapid eye movement (REM) and REM sleep, and clinical manifestations including daytime hypersomnolence, sleep attacks, and cataplexy. The hypocretin system regulates sleep/wake control through complex interactions between monoaminergic/cholinergic wake-promoting and GABAergic sleep-promoting neuronal systems. Research for the hypocretin agonist and the hypocretin antagonist for the treatment of sleep disorders has vigorously increased over the past 10 years. This review will focus on the origin, functions, and mechanisms in which the hypocretin system regulates sleep and wakefulness, and discuss its emerging role as a target for the treatment of sleep disorders.

引用

页码：227 / 234

页数：8

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