Rapidly progressive atherosclerosis after domino liver transplantation from a teenage donor with homozygous familial hypercholesterolemia

被引：12

作者：

Golbus, Jessica R. ^{[1
]}

Farhat, Linda ^{[1
]}

Fontana, Robert J. ^{[2
]}

Rubenfire, Melvyn ^{[1
]}

机构：

[1] Dept Internal Med, Div Cardiovasc Med, 1500 E Med Ctr Dr,SPC 5853, Ann Arbor, MI 48109 USA

[2] Dept Internal Med, Div Gastroenterol, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF CLINICAL LIPIDOLOGY | 2017年 / 11卷 / 05期

关键词：

Familial hypercholesterolemia; Homozygous familial hypercholesterolemia; Atherosclerotic cardiovascular disease; MANAGEMENT; SOCIETY; GRAFT;

D O I：

10.1016/j.jacl.2017.07.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by impaired clearance of low-density lipoprotein cholesterol. Given limitations in pharmacologic therapy and the significant morbidity and mortality associated with this disease, liver transplantation may be offered to select homozygous FH patients in childhood in an effort to slow progression of atherosclerotic cardiovascular disease. In rare cases, domino liver transplantation can be performed, transplanting the livers of patients with various metabolic disorders into elderly recipients whose projected survival precludes prolonged waiting on the transplant list. Herein, we report a case of domino liver transplantation using the liver of a 14-year-old boy with homozygous FH into a 65-year-old man with primary sclerosing cholangitis and cirrhosis who developed rapidly progressive atherosclerotic cardiovascular disease involving the arteries of his proximal bilateral lower extremities, carotid arteries and superior mesenteric artery. (C) 2017 National Lipid Association. All rights reserved.

引用

页码：1284 / 1288

页数：5

共 15 条

[1] Genetic identification of familial hypercholesterolemia within a single US health care system [J].

Abul-Husn, Noura S. ;

Manickam, Kandamurugu ;

Jones, Laney K. ;

Wright, Eric A. ;

Hartzel, Dustin N. ;

Gonzaga-Jauregui, Claudia ;

O'Dushlaine, Colm ;

Leader, Joseph B. ;

Kirchner, H. Lester ;

Lindbuchler, D'Andra M. ;

Barr, Marci L. ;

Giovanni, Monica A. ;

Ritchie, Marylyn D. ;

Overton, John D. ;

Reid, Jeffrey G. ;

Metpally, Raghu P. R. ;

Wardeh, Amr H. ;

Borecki, Ingrid B. ;

Yancopoulos, George D. ;

Baras, Aris ;

Shuldiner, Alan R. ;

Gottesman, Omri ;

Ledbetter, David H. ;

Carey, David J. ;

Dewey, Frederick E. ;

Murray, Michael F. .

SCIENCE, 2016, 354 (6319)

[2] Lipoprotein(a) Interactions With Low-Density Lipoprotein Cholesterol and Other Cardiovascular Risk Factors in Premature Acute Coronary Syndrome (ACS) [J].

Afshar, Mehdi ;

Pilote, Louise ;

Dufresne, Line ;

Engert, James C. ;

Thanassoulis, George .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (04)

[3] Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society [J].

Cuchel, Marina ;

Bruckert, Eric ;

Ginsberg, Henry N. ;

Raal, Frederick J. ;

Santos, Raul D. ;

Hegele, Robert A. ;

Kuivenhoven, Jan Albert ;

Nordestgaard, Borge G. ;

Descamps, Olivier S. ;

Steinhagen-Thiessen, Elisabeth ;

Tybjrg-Hansen, Anne ;

Watts, Gerald F. ;

Averna, Maurizio ;

Boileau, Catherine ;

Boren, Jan ;

Catapano, Alberico L. ;

Defesche, Joep C. ;

Hovingh, G. Kees ;

Humphries, Steve E. ;

Kovanen, Petri T. ;

Masana, Luis ;

Pajukanta, Paivi ;

Parhofer, Klaus G. ;

Ray, Kausik K. ;

Stalenhoef, Anton F. H. ;

Stroes, Erik ;

Taskinen, Marja-Riitta ;

Wiegman, Albert ;

Wiklund, Olov ;

Chapman, M. John .

EUROPEAN HEART JOURNAL, 2014, 35 (32) :2146-U100

[4] HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom [J].

France, Michael ;

Rees, Alan ;

Datta, Dev ;

Thompson, Gilbert ;

Capps, Nigel ;

Ferns, Gordon ;

Ramaswami, Uma ;

Seed, Mary ;

Neely, Dermot ;

Cramb, Robert ;

Shoulders, Carol ;

Barbir, Mahmoud ;

Pottle, Alison ;

Eatough, Ruth ;

Martin, Steven ;

Bayly, Graham ;

Simpson, Bill ;

Halcox, Julian ;

Edwards, Ray ;

Main, Linda ;

Payne, Jules ;

Soran, Handrean .

ATHEROSCLEROSIS, 2016, 255 :128-139

[5] Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia [J].

Khera, Amit V. ;

Won, Hong-Hee ;

Peloso, Gina M. ;

Lawson, Kim S. ;

Bartz, Traci M. ;

Deng, Xuan ;

van Leeuwen, Elisabeth M. ;

Natarajan, Pradeep ;

Emdin, Connor A. ;

Bick, Alexander G. ;

Morrison, Alanna C. ;

Brody, Jennifer A. ;

Gupta, Namrata ;

Nomura, Akihiro ;

Kessler, Thorsten ;

Duga, Stefano ;

Bis, Joshua C. ;

van Duijn, Cornelia M. ;

Cupples, L. Adrienne ;

Psaty, Bruce ;

Rader, Daniel J. ;

Danesh, John ;

Schunkert, Heribert ;

McPherson, Ruth ;

Farrall, Martin ;

Watkins, Hugh ;

Lander, Eric ;

Wilson, James G. ;

Correa, Adolfo ;

Boerwinkle, Eric ;

Merlini, Piera Angelica ;

Ardissino, Diego ;

Saleheen, Danish ;

Gabriel, Stacey ;

Kathiresan, Sekar .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (22) :2578-2589

[6] Domino liver graft from a patient with homozygous familial hypercholesterolemia [J].

Liu, Chinsu ;

Niu, Dau-Ming ;

Loong, Che-Chuan ;

Hsia, Cheng-Yuan ;

Tsou, Mei-Yung ;

Tsai, Hsin-Lin ;

Wei, Choufu .

PEDIATRIC TRANSPLANTATION, 2010, 14 (03) :E30-E33

[7] Long-term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation [J].

Lucey, Michael R. ;

Terrault, Norah ;

Ojo, Lolu ;

Hay, J. Eileen ;

Neuberger, James ;

Blumberg, Emily ;

Teperman, Lewis W. .

LIVER TRANSPLANTATION, 2013, 19 (01) :3-26

[8] Homozygous familial hypercholesterolemia: Specific indication for domino liver transplantation [J].

Popescu, I ;

Simionescu, M ;

Tulbure, D ;

Sima, A ;

Catana, C ;

Niculescu, L ;

Hancu, N ;

Gheorghe, L ;

Mihaila, M ;

Ciurea, S ;

Vidu, V .

TRANSPLANTATION, 2003, 76 (09) :1345-1350

[9] Domino liver transplantation using a graft from a donor with familial hypercholesterolemia: seven-yr follow-up [J].

Popescu, Irinel ;

Habib, Nagy ;

Dima, Simona ;

Hancu, Nicolae ;

Gheorghe, Liana ;

Iacob, Speranta ;

Mihaila, Mariana ;

Dorobantu, Bogdan ;

Matei, Emil ;

Botea, Florin .

CLINICAL TRANSPLANTATION, 2009, 23 (04) :565-570

[10] Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study [J].

Raal, Frederick J. ;

Hovingh, G. Kees ;

Blom, Dirk ;

Santos, Raul D. ;

Harada-Shiba, Mariko ;

Bruckert, Eric ;

Couture, Patrick ;

Soran, Handrean ;

Watts, Gerald F. ;

Kurtz, Christopher ;

Honarpour, Narimon ;

Tang, Lihua ;

Kasichayanula, Sree ;

Wasserman, Scott M. ;

Stein, Evan A. .

LANCET DIABETES & ENDOCRINOLOGY, 2017, 5 (04) :280-290

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