Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

被引：20

作者：

Farzaei, Mohammad Hosein ^{[1
,2
]}

Farzaei, Fatemeh ^{[3
]}

Gooshe, Maziar ^{[4
,5
]}

Abbasabadi, Zahra ^{[2
]}

Rezaei, Nima ^{[6
,7
,8
,9
]}

Abdolghaffari, Amir Hossein ^{[10
,11
]}

机构：

[1] Univ Tehran Med Sci, Dept Tradit Pharm, Fac Tradit Med, Tehran 1417653761, Iran

[2] Kermanshah Univ Med Sci, Fac Pharm, Kermanshah 6734667149, Iran

[3] Kermanshah Razi Univ, Coll Vet Med, Kermanshah 6715685414, Iran

[4] Univ Tehran Med Sci, Fac Med, Tehran 1417614411, Iran

[5] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran 1417614411, Iran

[6] Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies, Tehran, Iran

[7] Univ Tehran Med Sci, Mol Immunol Res Ctr, Tehran, Iran

[8] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[9] Univ Sheffield, Sch Med & Biomed Sci, Dept Infect & Immun, Sheffield, S Yorkshire, England

[10] Jahade Daneshgahi Res Soc, Supa, ACECR, Pharmacol & Appl Med Dept,Med Plants Res Ctr,Inst, Karaj Qazvin Freeway,POB 141554364, Karaj, Alborz, Iran

[11] Tehran Univ Med Sci ICTUMS, Tehran 1417653861, Iran

来源：

RHEUMATOLOGY INTERNATIONAL | 2015年 / 35卷 / 05期

关键词：

Osteoarthritis; Medicinal plant; Oxidative stress; Inflammation; Pro-inflammatory cytokine; Pain; RUTA-GRAVEOLENS L; COLCHICUM-LUTEUM BAKER; ACORUS-CALAMUS L; ANTIINFLAMMATORY ACTIVITY; OXIDATIVE STRESS; METHANOL EXTRACT; MYRTUS-COMMUNIS; ESSENTIAL OIL; ALOE-VERA; INHIBITS INFLAMMATION;

D O I：

10.1007/s00296-014-3175-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA.

引用

页码：799 / 814

页数：16

共 4 条

[1] Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis
Mohammad Hosein Farzaei
Fatemeh Farzaei
Maziar Gooshe
Zahra Abbasabadi
Nima Rezaei
Amir Hossein Abdolghaffari
Rheumatology International, 2015, 35 : 799 - 814
[2] Targeting TRPA1 with liposome-encapsulated drugs anchored to microspheres for effective osteoarthritis treatment
Chen, Yulin
Wang, Guangchao
Zhou, Fengjin
Yin, Zhifeng
Shen, Fuming
Weng, Weizong
Zhang, Hao
Jiang, Yingying
Liu, Xinru
Deng, Yonghui
Chen, Yuan
Xu, Ke
Su, Jiacan
CHINESE CHEMICAL LETTERS, 2025, 36 (05)
[3] The most effective corticosteroid dose in the treatment of glenohumeral osteoarthritis: Feasibility pilot and protocol for double blinded randomized controlled trial
Onks, Cayce
Weaver, Lynn
Latorre, Johan
Silvis, Matthew
Berg, Arthur
Phillips, Shawn
Loeffert, Jayson
French, Cristy
Armstrong, April
OSTEOARTHRITIS AND CARTILAGE OPEN, 2024, 6 (03):
[4] Natural remedies used by Bunong people in Mondulkiri province (Northeast Cambodia) with special reference to the treatment of 11 most common ailments
Chassagne, Francois
Hul, Sovanmoly
Deharo, Eric
Bourdy, Genevieve
JOURNAL OF ETHNOPHARMACOLOGY, 2016, 191 : 41 - 70

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