Indium(III) chloride catalyzed three-component coupling reaction: A novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents

被引：81
|
作者：
Reddy, B. V. Subba [1 ]
Reddy, M. Ramana [1 ]
Madan, Ch. [1 ]
Kumar, K. Pranay [2 ]
Rao, M. Srinivasa [2 ]
机构：
[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 24期
关键词：
Kojic acid; Indole; Aldehyde; Indium(III) halide; Antifungal and antibacterial activity; FRIEDEL-CRAFTS ALKYLATION; INDOLES; INCL3; AMINE;
D O I：
10.1016/j.bmcl.2010.10.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three-component coupling of aldehyde, indole and kojic acid has been achieved using a catalytic amount of InCl3 under solvent free conditions to produce a novel series of 2-substituted aryl( indolyl) kojic acid derivatives in good yields and with high selectivity. These compounds are found to exhibit potent antifungal properties. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7507 / 7511
页数：5
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