DSCAM, a highly conserved gene in mammals, expressed in differentiating mouse brain

被引：43

作者：

Agarwala, KL ^{[1
]}

Ganesh, S ^{[1
]}

Amano, K ^{[1
]}

Suzuki, T ^{[1
]}

Yamakawa, K ^{[1
]}

机构：

[1] RIKEN, Brain Sci Inst, Neurogenet Lab, Wako, Saitama 3510198, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 281卷 / 03期

关键词：

DSCAM; mouse; immunoglobulin superfamily; cell adhesion molecule; development; expression; Down syndrome;

D O I：

10.1006/bbrc.2001.4420

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Down Syndrome Cell Adhesion molecule (DSCAM) is a member of the immunoglobulin superfamily, and represents a novel class of neuronal cell adhesion molecules. In order to understand the cellular functions of DSCAM, we isolated full-length mouse and human cDNA clones, and analysed its expression during mouse development and differentiation. Sequence analysis of the human DSCAM cDNA predicted at least 33 exons that are distributed over 840 kb. When compared to human DSCAM, the mouse homologue showed 90 and 98% identity at the nucleotide and amino acid levels, respectively. In mouse, DSCAM is located on 16C, the syntenic region for human chromosome band 21q22 and also the region duplicated in mouse DS models. DSCAM gene is predicted to encode an similar to 220-kDa protein, and its expression shows dynamic changes that correlate with neuronal differentiation during mouse development. Our results suggest that DSCAM may play critical roles in the formation and maintenance of specific neuronal networks in brain, (C) 2001 Academic Press.

引用

页码：697 / 705

页数：9

共 31 条

[11] KINETICS OF HOMOPHILIC BINDING BY EMBRYONIC AND ADULT FORMS OF THE NEURAL CELL-ADHESION MOLECULE [J].

HOFFMAN, S ;

EDELMAN, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (18) :5762-5766

[12]

HOOK EB, 1981, TRISOMY, V21, P3

[13]

HUGH D, 2000, J NEUROSCI, V20, P5696

[14] ANOMALOUS BRAIN MORPHOLOGY ON MAGNETIC-RESONANCE IMAGES IN WILLIAMS SYNDROME AND DOWN SYNDROME [J].

JERNIGAN, TL ;

BELLUGI, U .

ARCHIVES OF NEUROLOGY, 1990, 47 (05) :529-533

[15] X-LINKED SPASTIC PARAPLEGIA (SPG1), MASA SYNDROME AND X-LINKED HYDROCEPHALUS RESULT FROM MUTATIONS IN THE L1 GENE [J].

JOUET, M ;

ROSENTHAL, A ;

ARMSTRONG, G ;

MACFARLANE, J ;

STEVENSON, R ;

PATERSON, J ;

METZENBERG, A ;

IONASESCU, V ;

TEMPLE, K ;

KENWRICK, S .

NATURE GENETICS, 1994, 7 (03) :402-407

[16] DOWN-SYNDROME PHENOTYPES - THE CONSEQUENCES OF CHROMOSOMAL IMBALANCE [J].

KORENBERG, JR ;

CHEN, XN ;

SCHIPPER, R ;

SUN, Z ;

GONSKY, R ;

GERWEHR, S ;

CARPENTER, N ;

DAUMER, C ;

DIGNAN, P ;

DISTECHE, C ;

GRAHAM, JM ;

HUGDINS, L ;

MCGILLIVRAY, B ;

MIYAZAKI, K ;

OGASAWARA, N ;

PARK, JP ;

PAGON, R ;

PUESCHEL, S ;

SACK, G ;

SAY, B ;

SCHUFFENHAUER, S ;

SOUKUP, S ;

YAMANAKA, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4997-5001

[17] THE HUMAN TAX1 GENE ENCODING THE AXON-ASSOCIATED CELL-ADHESION MOLECULE TAG-1/AXONIN-1 - GENOMIC STRUCTURE AND BASIC PROMOTER [J].

KOZLOV, SV ;

GIGER, RJ ;

HASLER, T ;

KORVATSKA, E ;

SCHORDERET, DF ;

SONDEREGGER, P .

GENOMICS, 1995, 30 (02) :141-148

[18] ECTOPIC AND INCREASED EXPRESSION OF FASCICLIN-II ALTERS MOTONEURON GROWTH CONE GUIDANCE [J].

LIN, DM ;

GOODMAN, CS .

NEURON, 1994, 13 (03) :507-523

[19] LOCATION OF THE MOUSE COMPLEMENT FACTOR-H GENE (CFH) BY FISH ANALYSIS AND REPLICATION R-BANDING [J].

MATSUDA, Y ;

HARADA, YN ;

NATSUUMESAKAI, S ;

LEE, K ;

SHIOMI, T ;

CHAPMAN, VM .

CYTOGENETICS AND CELL GENETICS, 1992, 61 (04) :282-&

[20] ORGANIZATION OF THE NEURAL CELL-ADHESION MOLECULE (N-CAM) GENE - ALTERNATIVE EXON USAGE AS THE BASIS FOR DIFFERENT MEMBRANE-ASSOCIATED DOMAINS [J].

OWENS, GC ;

EDELMAN, GM ;

CUNNINGHAM, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (01) :294-298

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