Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes.: Part 10

被引：23

作者：

Bottari, B

Maccari, R

Monforte, F

Ottanà, R

Rotondo, E

Vigorita, MG

机构：

[1] Univ Messina, Fac Farm, Dipartimento Farmacochim, I-98168 Messina, Italy

[2] Univ Messina, Fac Sci MMFFNN, Dipartimento Ch Inorg Anal & Ch Fis, I-98166 Messina, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00648-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Octahedral cobalt(II) complexes of isonicotinoylhydrazones. which were obtained from the primary antituberculous agent isoniazid, have been synthesised and characterised. Their antimycobacterial in vitro activity has been evaluated against Mycobacterium tuberculosis H37Rv: they exhibit MIC values ranging from < 0.1 to 0.19 <mu>g/mL, showing them to be generally more active than previously reported analogous Cu(II) and NI(II) complexes, (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：301 / 303

页数：3

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