Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

被引：22

作者：

Baldwin, Helen ^{[1
,2
]}

Radua, Joaquim ^{[1
,3
,4
]}

Antoniades, Mathilde ^{[5
]}

Haas, Shalaila S. ^{[5
]}

Frangou, Sophia ^{[5
,6
]}

Agartz, Ingrid ^{[7
,8
,9
,10
,11
]}

Allen, Paul ^{[12
,13
]}

Andreassen, Ole A. ^{[11
,14
,15
]}

Atkinson, Kimberley ^{[16
]}

Bachman, Peter ^{[17
]}

Baeza, Inmaculada ^{[18
]}

Bartholomeusz, Cali F. ^{[19
,20
]}

Chee, Michael W. L. ^{[21
]}

Colibazzi, Tiziano ^{[22
,23
]}

Cooper, Rebecca E. ^{[24
,25
]}

Corcoran, Cheryl M. ^{[5
,26
]}

Cropley, Vanessa L. ^{[24
,25
,27
]}

Ebdrup, Bjorn H. ^{[28
,29
]}

Fortea, Adriana ^{[30
]}

Glenthoj, Louise Birkedal ^{[31
]}

Hamilton, Holly K. ^{[32
,33
]}

Haut, Kristen M. ^{[34
]}

Hayes, Rebecca A. ^{[17
]}

He, Ying ^{[35
,36
]}

Heekeren, Karsten ^{[37
,38
]}

Kaess, Michael ^{[39
,40
]}

Kasai, Kiyoto ^{[41
,42
,43
]}

Katagiri, Naoyuki ^{[44
]}

Kim, Minah ^{[45
,46
]}

Kindler, Jochen ^{[40
]}

Klaunig, Mallory J. ^{[47
]}

Koike, Shinsuke ^{[42
,48
]}

Koppel, Alex ^{[49
]}

Kristensen, Tina D. ^{[28
,31
]}

Bin Kwak, Yoo ^{[50
,51
]}

Kwon, Jun Soo ^{[45
,46
]}

Lawrie, Stephen M. ^{[16
]}

Lebedeva, Irina ^{[52
]}

Lee, Jimmy ^{[51
,53
]}

Lin, Ashleigh ^{[54
]}

Loewy, Rachel L. ^{[32
]}

Mathalon, Daniel H. ^{[32
,33
]}

Michel, Chantal ^{[40
]}

Mizrahi, Romina ^{[55
,56
]}

Moller, Paul ^{[57
]}

Nelson, Barnaby ^{[19
,20
]}

Nemoto, Takahiro ^{[44
]}

Nordholm, Dorte ^{[31
]}

Omelchenko, Maria A. ^{[58
]}

Pantelis, Christos ^{[24
,25
,59
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England

[2] South London & Maudsley NHS Fdn Trust, Maudsley Biomed Res Ctr, Natl Inst Hlth Res, London, England

[3] CIBERSAM, Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain

[4] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[5] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[6] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[7] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[8] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden

[9] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden

[10] Univ Oslo, Norwegian Ctr Mental Disorders Res, Inst Clin Med, Oslo, Norway

[11] Univ Oslo, KG Jebsen Ctr Neurodev Disorders, Oslo, Norway

[12] Univ Roehampton, Dept Psychol, London, England

[13] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[14] Univ Oslo, Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT, Oslo, Norway

[15] Univ Oslo, Inst Clin Med, Oslo, Norway

[16] Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland

[17] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

[18] Univ Barcelona, Hosp Clin Barcelona,Ctr Invest Biomed Res Salud M, Dept Child & Adolescent Psychiat & Psychol, Inst Neurosci,Inst Invest Biomed August Pi i Suny, 2017SGR-881, Barcelona, Spain

[19] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[20] Orygen, Melbourne, Vic, Australia

[21] Natl Univ Singapore, Ctr Sleep & Cognit, Yong Loo Lin Sch Med, Singapore, Singapore

[22] Columbia Univ, Dept Psychiat, New York, NY USA

[23] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[24] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic, Australia

[25] Melbourne Hlth, Carlton, Vic, Australia

[26] James J Peters VA Med Ctr, Mental Illness Res Educ & Clin Ctr, New York, NY USA

[27] Swinburne Univ, Fac Hlth Arts & Design, Ctr Mental Hlth, Sch Hlth Sci, Melbourne, Vic, Australia

[28] Copenhagen Univ Hosp, Ctr Neuropsychiat Schizophrenia Res CNSR, Mental Hlth Ctr Glostrup, Glostrup, Denmark

[29] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[30] Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci,Fundacio Clin Recerca Biomed, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain

[31] Univ Copenhagen, Copenhagen Res Ctr Mental Hlth, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[32] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA

[33] San Francisco Vet Affairs Hlth Care Syst, San Francisco, CA USA

[34] Rush Univ Med Ctr, Dept Psychiat & Behav Sci, Chicago, IL USA

[35] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Peoples R China

[36] Cent South Univ, Dept Psychiat, Xiangya Hosp 2, Changsha, Peoples R China

[37] LVR Hosp Cologne, Dept Psychiat AndPsychotherapy 1, Cologne, Germany

[38] Univ Zurich, Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland

[39] Heidelberg Univ, Ctr Psychosocial Med, Dept Child & Adolescent Psychiat, Heidelberg, Germany

[40] Univ Bern, Univ Hosp Child & Adolescent Psychiat & Psychothe, Bern, Switzerland

[41] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Tokyo, Japan

[42] Univ Tokyo, Inst Divers & Adaptat Human Mind, Tokyo, Japan

[43] Univ Tokyo, Int Res Ctr Neurointelligence, Univ Tokyo Inst Adv Study, Tokyo, Japan

[44] Toho Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[45] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul, South Korea

[46] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea

[47] Univ Maryland Baltimore Cty, Dept Psychol, College Pk, MD USA

[48] Univ Tokyo, Ctr Evolutionary Cognit Sci, Grad Sch Art & Sci, Tokyo, Japan

[49] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[50] Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, Seoul, South Korea

来源：

TRANSLATIONAL PSYCHIATRY | 2022年 / 12卷 / 01期

基金：

英国医学研究理事会; 欧洲研究理事会; 美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;

关键词：

ULTRA-HIGH RISK; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; BRAIN STRUCTURE; SCHIZOPHRENIA; ONSET; ABNORMALITIES; SEGMENTATION; VULNERABILITY; VOLUME;

D O I：

10.1038/s41398-022-02057-y

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the 'normativeness' of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.

引用

页数：11

共 75 条

[51] Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison [J].

Pantelis, C ;

Velakoulis, D ;

McGorry, PD ;

Wood, SJ ;

Suckling, J ;

Phillips, LJ ;

Yung, AR ;

Bullmore, ET ;

Brewer, W ;

Soulsby, B ;

Desmond, P ;

McGuire, PK .

LANCET, 2003, 361 (9354) :281-288

[52] Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia [J].

Provenzano, Frank A. ;

Guo, Jia ;

Wall, Melanie M. ;

Feng, Xinyang ;

Sigmon, Hannah C. ;

Brucato, Gary ;

First, Michael B. ;

Rothman, Douglas L. ;

Girgis, Ragy R. ;

Lieberman, Jeffrey A. ;

Small, Scott A. .

BIOLOGICAL PSYCHIATRY, 2020, 87 (03) :234-242

[53]

R Core Team, 2020, R LANGUAGE ENV STAT

[54] Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA [J].

Radua, Joaquim ;

Vieta, Eduard ;

Shinohara, Russell ;

Kochunov, Peter ;

Quide, Yann ;

Green, Melissa J. ;

Weickert, Cynthia S. ;

Weickert, Thomas ;

Bruggemann, Jason ;

Kircher, Tilo ;

Nenadic, Igor ;

Cairns, Murray J. ;

Seal, Marc ;

Schall, Ulrich ;

Henskens, Frans ;

Fullerton, Janice M. ;

Mowry, Bryan ;

Pantelis, Christos ;

Lenroot, Rhoshel ;

Cropley, Vanessa ;

Loughland, Carmel ;

Scott, Rodney ;

Wolf, Daniel ;

Satterthwaite, Theodore D. ;

Tan, Yunlong ;

Sim, Kang ;

Piras, Fabrizio ;

Spalletta, Gianfranco ;

Banaj, Nerisa ;

Pomarol-Clotet, Edith ;

Solanes, Aleix ;

Albajes-Eizagirre, Anton ;

Canales-Rodriguez, Erick J. ;

Sarro, Salvador ;

Di Giorgio, Annabella ;

Bertolino, Alessandro ;

Staeblein, Michael ;

Oertel, Viola ;

Knoechel, Christian ;

Borgwardt, Stefan ;

du Plessis, Stefan ;

Yun, Je-Yeon ;

Kwon, Jun Soo ;

Dannlowski, Udo ;

Hahn, Tim ;

Grotegerd, Dominik ;

Alloza, Clara ;

Arango, Celso ;

Janssen, Joost ;

Diaz-Caneja, Covadonga .

NEUROIMAGE, 2020, 218

[55] Evaluation of variability in individual response to treatments in the clinical high-risk state for psychosis: A meta-analysis [J].

Radua, Joaquim ;

Davies, Cathy ;

Fusar-Poli, Paolo .

SCHIZOPHRENIA RESEARCH, 2021, 227 :20-27

[56] What causes psychosis? An umbrella review of risk and protective factors [J].

Radua, Joaquim ;

Ramella-Cravaro, Valentina ;

Ioannidis, John P. A. ;

Reichenberg, Abraham ;

Phiphopthatsanee, Nacharin ;

Amir, Taha ;

Thoo, Hyi Yenn ;

Oliver, Dominic ;

Davies, Cathy ;

Morgan, Craig ;

McGuire, Philip ;

Murray, Robin M. ;

Fusar-Poli, Paolo .

WORLD PSYCHIATRY, 2018, 17 (01) :49-66

[57] Effects of Cannabis Use on Human Brain Structure in Psychosis: A Systematic Review Combining In Vivo Structural Neuroimaging and Post Mortem Studies [J].

Rapp, Charlotte ;

Bugra, Hilal ;

Riecher-Roessler, Anita ;

Tamagni, Corinne ;

Borgwardt, Stefan .

CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (32) :5070-5080

[58] Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis [J].

Rutigliano, Grazia ;

Valmaggia, Lucia ;

Landi, Paola ;

Frascarelli, Marianna ;

Cappucciati, Marco ;

Sear, Victoria ;

Rocchetti, Matteo ;

De Micheli, Andrea ;

Jones, Ceri ;

Palombini, Erika ;

McGuire, Philip ;

Fusar-Poli, Paolo .

JOURNAL OF AFFECTIVE DISORDERS, 2016, 203 :101-110

[59] Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms [J].

Satterthwaite, Theodore D. ;

Wolf, Daniel H. ;

Calkins, Monica E. ;

Vandekar, Simon N. ;

Erus, Guray ;

Ruparel, Kosha ;

Roalf, David R. ;

Linn, Kristin A. ;

Elliott, Mark A. ;

Moore, Tyler M. ;

Hakonarson, Hakon ;

Shinohara, Russell T. ;

Davatzikos, Christos ;

Gur, Ruben C. ;

Gur, Raquel E. .

JAMA PSYCHIATRY, 2016, 73 (05) :515-524

[60]

Schwarzer G., 2012, R FDN STAT COMPUTING

← 1 2 3 4 5 6 7 8 →