Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers

被引：50
|
作者：
Shah, Atman Prabodh
Ichiuji, Anne Marie
Han, Janet K.
Traina, Mahmoud
El-Bialy, Adel
Meymandi, Sheba Kamal
Wachsner, Robin Yvonne
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Harbor UCLA Med Ctr, St Johns Cardiovasc Res Ctr, Torrance, CA 90502 USA
[2] Univ Calif Los Angeles, Olive View Med Ctr Sylmar, Los Angeles, CA USA
[3] Greater Los Angeles VA Healthcare, Los Angeles, CA USA
[4] Kaiser Permanente Med Ctr, Div Cardiol, Los Angeles, CA 90034 USA
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS | 2007年 / 12卷 / 03期
关键词：
endothelium; fish oil; hemodynamics;
D O I：
10.1177/1074248407304749
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Consumption of fish oil (FO) is associated with reduced adverse cardiovascular events. In a randomized, blinded, placebo-controlled trial, 26 subjects (17 men and 9 women; mean age [ +/- SD] 31 +/- 3.7 years) received 1 g FO capsule (n = 14) or placebo (1 g of corn oil, n = 12) for 14 days. At day 0 and day 14, heart rate (HR), blood pressure, endothelium-dependent brachial artery flow-mediated vasodilation (EDV), and endothelium-independent nitroglycerin-mediated vasodilation (EIDV) were assessed with ultrasound. FO supplementation resulted in a significant increase in EDV (20.4% +/- 13.2% vs 9.9% +/- 5.4%; P = .036) and EIDV (32.6% +/- 16.8% vs 18.0% +/- 14.9%; P = .043 ). Resting HR decreased by a mean of 5.9 +/- 9.4 bpm (FO) compared with placebo (mean increase of 0.73 +/- 4.8 bpm [P = .05]). FO supplementation in healthy subjects is associated with improved endothelial function and decreased resting HR.
引用
收藏
页码：213 / 219
页数：7
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