Influence of Glutamate Dehydrogenase Activity on L-Proline Synthesis

被引：0

作者：

Keleshyan, S. K. ^{[1
]}

Karapetyan, Zh. V. ^{[1
]}

Chakhalyan, A. Kh. ^{[1
]}

Hovhannisyan, N. A. ^{[1
,2
]}

Avetisova, G. Ye. ^{[1
,2
]}

Chitchyan, M. B. ^{[1
]}

Oganezova, G. G. ^{[1
]}

Melkumyan, M. A. ^{[1
]}

Avetisyan, N. S. ^{[1
]}

Melkonyan, L. H. ^{[1
,2
]}

机构：

[1] Natl Acad Sci, SPC Armbiotechnol, Yerevan 0056, Armenia

[2] Yerevan State Univ, Yerevan 0025, Armenia

来源：

APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2017年 / 53卷 / 05期

关键词：

Brevibacterium flavum; producer strain; L-proline; fermentation; plasmid; shuttle vector; CORYNEBACTERIUM-GLUTAMICUM; BREVIBACTERIUM-FLAVUM; AMINO-ACIDS; BACTERIUM; ASSIMILATION; EXPRESSION; CLONING; GENE;

D O I：

10.1134/S0003683817050064

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The influence of glutamate dehydrogenase activity on the production of L-proline in the producer strain Brevibacterium flavum AP111 was studied. Transformants of the Brevibacterium flavum strain AP111 were obtained with the use of a recombinant plasmid previously constructed by us, pVOG10. It includes the encoding sequence of the gdh gene, which is responsible for the synthesis of glutamate dehydrogenase. The production of L-proline in transformants was shown to have increased by more than 40%. The results can serve as the basis for the use of this approach to improve strains producing other amino acids of the glutamine family.

引用

页码：518 / 523

页数：6

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