MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia

被引：9

作者：

Del Gaizo, Martina ^{[1
]}

Sergio, Ilaria ^{[2
]}

Lazzari, Sara ^{[1
]}

Cialfi, Samantha ^{[1
]}

Pelullo, Maria ^{[3
]}

Screpanti, Isabella ^{[1
]}

Felli, Maria Pia ^{[2
]}

机构：

[1] Sapienza Univ Rome, Dept Mol Med, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy

[3] Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, I-00161 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 02期

关键词：

microRNA; Notch; Natural Killer cells; T and regulatory T cells; MDSC; Acute lymphoblastic leukaemia; SUPPRESSOR-CELLS; TUMOR-SUPPRESSOR; MOLECULAR-MECHANISMS; NK CELLS; NOTCH; EXPRESSION; ACTIVATION; INFLAMMATION; REVEALS; EVASION;

D O I：

10.3390/ijms23020829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field.

引用

页数：19

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