Pathways to immunity: temporal dynamics of the bumblebee (Bombus terrestris) immune response against a trypanosomal gut parasite

被引：40

作者：

Riddell, C. E. ^{[1
]}

Sumner, S. ^{[2
]}

Adams, S. ^{[3
]}

Mallon, E. B. ^{[4
]}

机构：

[1] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 3JT, Midlothian, Scotland

[2] Zool Soc London, Inst Zool, London NW1 4RY, England

[3] Univ Warwick, Coventry CV4 7AL, W Midlands, England

[4] Univ Leicester, Dept Biol, Leicester, Leics, England

来源：

INSECT MOLECULAR BIOLOGY | 2011年 / 20卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Crithidia bombi; subtractive suppression hybridization; antimicrobial peptides; ecological immunology; DROSOPHILA HOST-DEFENSE; GENOME-WIDE ANALYSIS; ANOPHELES-GAMBIAE; CRITHIDIA-BOMBI; ANTIMICROBIAL PEPTIDES; INVERTEBRATE IMMUNITY; GENETIC-VARIATION; APIS-MELLIFERA; SOCIAL INSECTS; INFECTION;

D O I：

10.1111/j.1365-2583.2011.01084.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immune response dynamics in insects from natural host-parasite associations are poorly understood, despite accumulating evidence of ecological immune phenomena in these systems. Using a gene discovery approach, we have identified genes relating to signalling, enzymatic processes and respiration that were up-regulated in the bumblebee, Bombus terrestris, during infection with the trypanosomatid parasite, Crithidia bombi. In addition, we have mapped dynamic changes in the temporal expression of these genes and three candidate antimicrobial peptide (AMP) immune genes, Abaecin, Defensin and Hymenoptaecin, from 1 to 24 h after C. bombi infection. We show that dynamic changes in expression occur for individual genes at distinct phases of the immune response to C. bombi that correspond to early, intermediate and late stages of infection.

引用

页码：529 / 540

页数：12

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