ABCB1 gene polymorphisms and response to chemotherapy in breast cancer patients: A meta-analysis

被引：18
作者：
Madrid-Paredes, Adela [1 ,2 ]
Canadas-Garre, Marisa [1 ,3 ]
Sanchez-Pozo, Antonio [2 ]
Exposito-Ruiz, Manuela [4 ]
Angel Calleja-Hernandez, Miguel [1 ]
机构：
[1] Inst Invest Biosanitaria Granada, Pharmacogenet Unit, UGC Prov Farm Granada, Complejo Hosp Univ Granada,Avda Fuerzas Armadas 2, Granada, Spain
[2] Univ Granada, Fac Pharm, Dept Biochem, Campus Univ Cartuja S-N, E-18071 Granada, Spain
[3] Queens Univ Belfast, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Inst Clin Sci,Royal Victoria Hosp, Block B,Grosvenor Rd, Belfast BT12 6BJ, Antrim, North Ireland
[4] FIBAO, Av Fuerzas Armadas 2,1a Planta Biblioteca, Granada 18014, Spain
来源：
SURGICAL ONCOLOGY-OXFORD | 2017年 / 26卷 / 04期
关键词：
Meta-analysis; ABCB1; C3435T; C1236T; Breast; Cancer; MDR1 C3435T POLYMORPHISM; CLINICAL-OUTCOMES; NEOADJUVANT CHEMOTHERAPY; RANDOMIZED-TRIALS; DRUG-RESISTANCE; P-GLYCOPROTEIN; ASSOCIATION; RISK;
D O I：
10.1016/j.suronc.2017.09.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The ABCB1 gene encodes the P-glycoprotein, an efflux pump for some antineoplastic agents which acts as a resistance mechanism to chemotherapy. Three SNPs (C3435T, C1236T and G2677T/A), are the most widely studied in ABCB1. The inconsistent conclusions about the association of these polymorphisms and the response to chemotherapy in breast cancer (BC) patients prompted us to conduct a meta-analysis. A total of nine (770 patients), five (566 patients) and three studies (367 patients) relating the ABCB1 C3435T, C1236T and G2677T/A polymorphisms respectively, were included. The main analysis revealed a lack of association between ABCB1 polymorphisms and response to chemotherapy in every genetic model: C3435T (dominant OR: 0.888; 95% CI: 0.558-1.413), C1236T (dominant OR: 1.968; 95% CI: 0.609-6.362) and G2677T/A (GG vs GT + GA + TT + TA + AA OR: 0.854; 95% CI: 0.418-1.744). Stratification by ethnicity, cancer type and response criteria did not change the pattern of results. The available evidence indicates that three polymorphisms within ABCB1; C3435T, C1236T and G2677T/A, cannot be considered a reliable predictor of response to chemotherapy in BC patients. (C)2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：473 / 482
页数：10
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