Label-free DNA detection based on whispering gallery mode optofluidic microcavity biosensor

被引：2
|
作者：
Fu, Liang [1 ]
Chen, Xiaogang [1 ]
Lu, Qijing [1 ]
Xie, Shusen [1 ]
机构：
[1] Fujian Normal Univ, Prov Key Lab Photon Technol, Minist Educ, Key Lab Optoelect Sci & Technol Med, Fuzhou 350007, Fujian, Peoples R China
来源：
NANOPHOTONICS AND MICRO/NANO OPTICS IV | 2018年 / 10823卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Biosensor; microcavity; single strand DNA; coupling depth; SHIFT;
D O I：
10.1117/12.2501139
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We proposed and experimentally demonstrated a sensitive, label-free, real-time and low-cost optofluidic microcavity biosensor for DNA detection. The change of whispering gallery mode (WGM) resonant wavelength is monitored by data acquisition card in real-time. The experimental results show that the biosensor can significantly distinguish the non-complementary single strand (ssDNA), single nucleotide mismatch ssDNA, and target ssDNA. In addition, a sensing mechanism based on WGM coupling depth was also experimentally demonstrated which would have potential for detection of biological and chemical analytes in the future.
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页数：6
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