Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis

被引：6

作者：

Kacperczyk-Bartnik, Joanna ^{[1
,2
]}

Bartnik, Pawel ^{[1
,2
]}

Golawski, Ksawery ^{[3
]}

Sierdzinski, Janusz ^{[4
]}

Manka, Grzegorz ^{[5
]}

Kiecka, Mariusz ^{[5
]}

Lipa, Michal ^{[2
,3
]}

Warzecha, Damian ^{[3
]}

Spaczynski, Robert ^{[6
]}

Piekarski, Piotr ^{[6
]}

Banaszewska, Beata ^{[7
]}

Jakimiuk, Artur ^{[8
,9
]}

Issat, Tadeusz ^{[8
,10
]}

Rokita, Wojciech ^{[11
,12
]}

Mlodawski, Jakub ^{[11
,12
]}

Szubert, Maria ^{[2
,13
,14
]}

Sieroszewski, Piotr ^{[13
,15
]}

Raba, Grzegorz ^{[16
,17
]}

Szczupak, Kamil ^{[16
,17
]}

Kluz, Tomasz ^{[18
]}

Kluza, Marek ^{[18
]}

Czajkowski, Krzysztof ^{[1
]}

Wielgos, Miroslaw ^{[3
]}

Koc-Zorawska, Ewa ^{[19
]}

Zorawski, Marcin ^{[20
]}

Laudanski, Piotr ^{[3
,21
]}

机构：

[1] Med Univ Warsaw, Dept Obstet & Gynecol 2, PL-02091 Warsaw, Poland

[2] Polish Soc Gynecologists & Obstetricians, Club 35, PL-53125 Wroclaw, Poland

[3] Med Univ Warsaw, Dept Obstet & Gynecol 1, PL-02091 Warsaw, Poland

[4] Med Univ Warsaw, Dept Med Informat & Telemed, PL-00581 Warsaw, Poland

[5] Angelius Provita Hosp, PL-40611 Katowice, Poland

[6] Poznan Univ Med Sci, Div Infertil & Reprod Endocrinol, Dept Gynecol Obstet & Gynecol Oncol, PL-60512 Poznan, Poland

[7] Poznan Univ Med Sci, Chair & Dept Lab Diagnost, PL-60512 Poznan, Poland

[8] Minist Interior, Dept Obstet & Gynecol, Cent Clin Hosp, PL-02507 Warsaw, Poland

[9] Inst Mother & Child Warsaw, Ctr Reprod Hlth, PL-01211 Warsaw, Poland

[10] Inst Mother & Child Warsaw, Dept Obstet & Gynecol, PL-01211 Warsaw, Poland

[11] Jan Kochanowski Univ Kielce, Coll Med, PL-25369 Kielce, Poland

[12] Prov Combined Hosp Kielce, Clin Obstet & Gynecol, PL-25736 Kielce, Poland

[13] Med Univ Lodz, Dept Gynecol & Obstet, PL-90419 Lodz, Poland

[14] Med Univ Lodz, Dept Surg Gynecol & Oncol, PL-90419 Lodz, Poland

[15] Med Univ Lodz, Dept Fetal Med & Gynecol, PL-90419 Lodz, Poland

[16] Clin Obstet & Gynecol Przemysl, PL-37700 Przemysl, Poland

[17] Univ Rzeszow, Dept Obstet & Gynecol, PL-35330 Rzeszow, Poland

[18] Rzeszow Univ, Med Coll, Dept Gynecol Gynecol Oncol & Obstet, Inst Med Sci, PL-35310 Rzeszow, Poland

[19] Med Univ Bialystok, Dept Nephrol & Hypertens 2, Dialysis Unit, PL-15089 Bialystok, Poland

[20] Med Univ Bialystok, Dept Clin Med, PL-15089 Bialystok, Poland

[21] OVIklin Infertil Ctr, PL-01377 Warsaw, Poland

来源：

BIOMEDICINES | 2022年 / 10卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

endometriosis; ELISA; infertility; PARP; peritoneal fluid; plasma; WOMEN; PARP-1; INHIBITION; CANCER; POLY(ADP-RIBOSYL)ATION; TRANSCRIPTION; MELANOMA; NAD(+); RISK;

D O I：

10.3390/biomedicines10102451

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evidence of poly (ADP-ribose) polymerase (PARP) association with the immune response could be coherent with the immunological theory of endometriosis and suggests the possibility of a new research direction. The aim of the study was to evaluate the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. It was a multicenter, cross-sectional study. Plasma and peritoneal fluid samples were collected from patients with and without endometriosis during planned laparoscopic procedures in eight clinical centers. In total, 84 samples of plasma and 84 samples of the peritoneal fluid were included in the final analyses. Double-antibody sandwich enzyme-linked immunosorbent assay was performed in order to assess levels of PARP in collected samples. No statistically significant differences regarding the detected levels of PARP in plasma and peritoneal fluid comparing patients with and without endometriosis were observed. Patients with a history of infertility had significantly higher plasma PARP concentrations (p = 0.04). We have not observed the potential role of PARP concentration levels in plasma nor peritoneal fluid as an endometriosis biomarker. We have determined an association between a higher plasma PARP concentration and a history of infertility.

引用

页数：10

共 47 条

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