共 76 条
Pharmacological properties of SD-282 -: An α-isoform selective inhibitor for p38 MAP kinase
被引:9
作者:
Koppelman, Bruce
[1
]
Webb, Heather K.
[1
,2
]
Medicherla, Satyanarayana
[1
,3
]
Almirez, Ramona
[1
,4
]
Feng, Ying
[1
]
Chavez, Jose Carlos
[1
]
Mao, Cheng Ping
[1
]
Nguyen, Aaron
[7
]
Liu, Yu-Wang
[1
,4
]
Kapoun, Ann M.
[1
,5
]
Muiru, Gladys
[1
]
Huang, Yuanying Anne
[1
]
Dugar, Sundeep
[1
,9
]
Mavunkel, Babu J.
[1
]
Lim, Don W.
[1
]
Chakravarty, Sarvajit
[1
,6
]
Luedtke, Gregory
[1
,9
]
Protter, Andrew A.
[1
,6
]
Higgins, Linda S.
[1
,8
]
机构:
[1] Scios Inc, Fremont, CA USA
[2] Arete Therapeut, Hayward, CA USA
[3] Schering Plough Biopharma, Palo Alto, CA USA
[4] Alza, Mountain View, CA USA
[5] Oncomed Pharmaceut, Redwood City, CA USA
[6] Medivat Inc, San Francisco, CA USA
[7] Pharmion Corp, San Francisco, CA USA
[8] InteKrin Therapeut, Los Altos, CA USA
[9] Sai Life Sci Ltd, Hyderabad, Andhra Pradesh, India
关键词:
p38 MAP kinase;
inflammation;
cytokine;
asthma;
sepsis;
D O I:
10.1159/000112865
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation. Copyright (C) 2008 S. Karger AG, Basel.
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页码:204 / 220
页数:17
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