Pharmacological properties of SD-282 -: An α-isoform selective inhibitor for p38 MAP kinase

被引:9
作者
Koppelman, Bruce [1 ]
Webb, Heather K. [1 ,2 ]
Medicherla, Satyanarayana [1 ,3 ]
Almirez, Ramona [1 ,4 ]
Feng, Ying [1 ]
Chavez, Jose Carlos [1 ]
Mao, Cheng Ping [1 ]
Nguyen, Aaron [7 ]
Liu, Yu-Wang [1 ,4 ]
Kapoun, Ann M. [1 ,5 ]
Muiru, Gladys [1 ]
Huang, Yuanying Anne [1 ]
Dugar, Sundeep [1 ,9 ]
Mavunkel, Babu J. [1 ]
Lim, Don W. [1 ]
Chakravarty, Sarvajit [1 ,6 ]
Luedtke, Gregory [1 ,9 ]
Protter, Andrew A. [1 ,6 ]
Higgins, Linda S. [1 ,8 ]
机构
[1] Scios Inc, Fremont, CA USA
[2] Arete Therapeut, Hayward, CA USA
[3] Schering Plough Biopharma, Palo Alto, CA USA
[4] Alza, Mountain View, CA USA
[5] Oncomed Pharmaceut, Redwood City, CA USA
[6] Medivat Inc, San Francisco, CA USA
[7] Pharmion Corp, San Francisco, CA USA
[8] InteKrin Therapeut, Los Altos, CA USA
[9] Sai Life Sci Ltd, Hyderabad, Andhra Pradesh, India
关键词
p38 MAP kinase; inflammation; cytokine; asthma; sepsis;
D O I
10.1159/000112865
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码:204 / 220
页数:17
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