Cervical human papillomavirus infection in women with preterm prelabor rupture of membranes

被引：10

作者：

Hornychova, Helena ^{[1
]}

Kacerovsky, Marian ^{[2
,3
]}

Musilova, Ivana ^{[2
]}

Pliskova, Lenka ^{[4
]}

Zemlickova, Helena ^{[5
]}

Matejkova, Adela ^{[1
]}

Vosmikova, Hana ^{[1
]}

Rozkosova, Katerina ^{[1
]}

Cermakova, Petra ^{[1
]}

Bolehovska, Radka ^{[4
]}

Halada, Petr ^{[2
]}

Jacobsson, Bo ^{[6
,7
]}

Laco, Jan ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Med Hradec Kralove, Univ Hosp Hradec Kralove, Fingerland Dept Pathol, Hradec Kralove, Czech Republic

[2] Charles Univ Prague, Fac Med Hradec Kralove, Univ Hosp Hradec Kralove, Dept Obstet & Gynecol, Hradec Kralove, Czech Republic

[3] Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove, Czech Republic

[4] Charles Univ Prague, Fac Med Hradec Kralove, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Hradec Kralove, Czech Republic

[5] Charles Univ Prague, Fac Med Hradec Kralove, Univ Hosp Hradec Kralove, Dept Microbiol, Hradec Kralove, Czech Republic

[6] Gothenburg Univ, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden

[7] Inst Publ Hlth, Domain Hlth Data & Digitalisat, Dept Genet & Bioinformat, Oslo, Norway

来源：

PLOS ONE | 2018年 / 13卷 / 11期

关键词：

PARAFFIN-EMBEDDED TISSUES; HERPES-SIMPLEX-VIRUS; REAL-TIME PCR; PREGNANT-WOMEN; AMNIOTIC-FLUID; PREMATURE RUPTURE; VIRAL-INFECTIONS; RISK-FACTORS; INTRAAMNIOTIC COMPLICATIONS; PLACENTAL INFLAMMATION;

D O I：

10.1371/journal.pone.0207896

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective To evaluate the association between cervical human papillomavirus (HPV) infection at the time of admission and the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI) in women with preterm prelabor rupture of membranes (PPROM) and to determine the association between cervical HPV infection and short-term neonatal morbidity. Methods One hundred women with singleton pregnancies complicated by PPROM between the gestational ages of 24+0 and 36+6 weeks were included in the study. The presence of HPV DNA was evaluated in scraped cervical cells using polymerase chain reaction (PCR). Amniotic fluid samples were obtained by transabdominal amniocentesis. Results The rate of cervical HPV infection in women with PPROM was 24%. The rates of MIAC and IAI were not different between women with cervical HPV infection and those without cervical HPV infection [MIAC: with HPV: 21% (5/24) vs. without HPV: 22% (17/76), p= 1.00; IAI: with HPV: 21% (5/24) vs. without HPV: 18% (14/76), p = 0.77]. There were no differences in the selected aspects of short-term neonatal morbidity between women with and without cervical HPV infection. Conclusions In women with PPROM, the presence of cervical HPV infection at the time of admission is not related to a higher risk of intra-amniotic infection-related and inflammatory complications or worse short-term neonatal outcomes.

引用

页数：17