Aminolevulinic acid with gold nanoparticles: a novel theranostic agent for atherosclerosis

被引：28
作者：
Goncalves, Karina de Oliveira [1 ]
da Silva, Monica Nascimento [1 ]
Sicchieri, Leticia Bonfante [2 ]
de Oliveira Silva, Flavia Rodrigues [3 ]
de Matos, Ricardo Almeida [1 ]
Courrol, Lilia Coronato [1 ,2 ]
机构：
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Exatas & Terra, Lab Lasers & Opt Biomed Aplicada LOBA, BR-09972270 Diadema, SP, Brazil
[2] Inst Pesquisas Energet & Nucl, Ctr Lasers & Aplicacoes, Sao Paulo, SP, Brazil
[3] Inst Pesquisas Energet & Nucl, Ctr Ciencia & Tecnol Mat, Sao Paulo, SP, Brazil
来源：
ANALYST | 2015年 / 140卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
MEDIATED SONODYNAMIC THERAPY; PHOTODYNAMIC THERAPY; 5-AMINOLEVULINIC ACID; PROTOPORPHYRIN IX; CANCER; PROGRESSION; MACROPHAGES; DIAGNOSIS; PLAQUES;
D O I：
10.1039/c4an02166e
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In this study, 5-aminolevulinic acid (ALA) gold nanoparticles (ALA:AuNPs) functionalized with polyethylene glycol (PEG) were synthesized and administered to rabbits to evaluate their use in clinical practice as theranostic agents for atherosclerosis. This was done by measuring the porphyrin fluorescence extracted from the rabbits' blood and feces. An increase in blood and feces porphyrin emission after ALA: AuNP administration suggests that ALA was incorporated by gold nanoparticles, its structure was preserved, and a rapid conversion into endogenous porphyrins occurred, overloading the synthetic pathway that led to protoporphyrin IX (PPIX) accumulation. This finding indicated that this method can aid in the early diagnosis and therapy of atherosclerosis with high sensitivity.
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页码：1974 / 1980
页数：7
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