Synthesis and Application of a Thermoplastic Plate of Poly(lactide-ε-caprolactone) for Radiation Therapy

被引：3

作者：

Li, Hongli ^{[1
]}

Li, Wenzhi ^{[1
]}

Wu, Hongtao ^{[1
]}

Jiang, Dengbang ^{[1
]}

Yuan, Mingwei ^{[1
]}

Yuan, Minglong ^{[1
]}

机构：

[1] Yunnan Minzu Univ, Green Preparat Technol Biobased Mat Natl & Local, Kunming 650500, Yunnan, Peoples R China

来源：

BIOMOLECULES | 2020年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

poly(lactide-epsilon-caprolactone) copolymer; triallyl isocyanurate; shape memory; thermoplastic plate; mechanical property; RING-OPENING POLYMERIZATION; EPSILON-CAPROLACTONE; CROSS-LINKING; MECHANICAL-PROPERTIES; DL-LACTIDE; POLY(EPSILON-CAPROLACTONE); LACTONES; NANOCOMPOSITE; STEREOCOMPLEX; NETWORKS;

D O I：

10.3390/biom10010027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, the poly(lactide-epsilon-caprolactone) (P(LA-CL)) copolymer is synthesized by ring-opening polymerization with glycol used as a molecular weight regulator to adjust the molecular weight of the polymer. The proton nuclear magnetic resonance spectroscopy and gel permeation chromatography (GPC) results demonstrate that the P(LA-CL) copolymer is successfully synthesized, and that the molecular weight can be controlled by the glycol content. The thermoplastic plate is processed with triallyl isocyanurate as a cross-linking agent by a single-screw extruder followed by gamma-ray irradiation. Shape memory test results show that the material had the desired shape memory effect, with deformation recovery rates reaching 100%. After secondary stretching of samples, deformation recovery rates are unchanged. The results of mechanical property measurements indicate that with added lactide, the tensile strength is improved and shore hardness is increased by 20%-30%. Data from clinical trials also reveal that the material has good clinical effects in thermoplastic membrane fixation.

引用

页数：13

共 33 条

[11] Hollow fibers of poly(lactide-co-glycolide) and poly(ε-caprolactone) blends for vascular tissue engineering applications [J].