IFALD in children: What's new? A narrative review

被引:9
作者
Di Dato, Fabiola [1 ]
Iorio, Raffaele [1 ]
Spagnuolo, Maria Immacolata [1 ]
机构
[1] Univ Naples Federico II, Dept Translat Med Sci, Sect Pediat, Naples, Italy
关键词
intestinal failure; parenteral nutrition; cholestasis; liver transplantation; children; TOTAL PARENTERAL-NUTRITION; ISOLATED LIVER-TRANSPLANTATION; INTRAVENOUS LIPID EMULSIONS; INTESTINAL FAILURE; URSODEOXYCHOLIC ACID; PEDIATRIC-PATIENTS; ASPARTATE-AMINOTRANSFERASE; RATIO INDEX; DISEASE; CHOLESTASIS;
D O I
10.3389/fnut.2022.928371
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Intestinal failure-associated liver disease (IFALD) is a progressive liver disease complicating intestinal failure (IF). It is a preventable and reversible condition, but at the same time, a potential cause of liver cirrhosis and an indication to combined or non-combined liver and small bowel transplantation. The diagnostic criteria are not yet standardized, so that its prevalence varies widely in the literature. Pathophysiology seems to be multifactorial, related to different aspects of intestinal failure and not only to the long-term parenteral nutrition treatment. The survival rates of children with IF have increased, so that the main problems today are preventing complications and ensuring a good quality of life. IFALD is one of the most important factors that limit long-term survival of patients with IF. For this reason, more and more interest is developing around it and the number of published articles is increasing rapidly. The purpose of this narrative review was to focus on the main aspects of the etiology, pathophysiology, management, prevention, and treatment of IFALD, based on what has been published mainly in the last 10 years. Controversies and current research gaps will be highlighted with the aim to pave the way for new project and high-quality clinical trials.
引用
收藏
页数:13
相关论文
共 87 条
[1]   Effects of cyclic parenteral nutrition on parenteral nutrition-associated cholestasis in newborns [J].
Bae, Hye Jung ;
Shin, Seung Han ;
Kim, Ee-Kyung ;
Kim, Han-Suk ;
Cho, Yoon Sook ;
Gwak, Hye Sun .
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION, 2019, 28 (01) :42-48
[2]   Characterization of Fatty Acid Profiles in Infants With Intestinal Failure-Associated Liver Disease [J].
Baker, Meredith A. ;
Mitchell, Paul D. ;
O'Loughlin, Alison A. ;
Potemkin, Alexis K. ;
Anez-Bustillos, Lorenzo ;
Dao, Duy T. ;
Fell, Gillian L. ;
Gura, Kathleen M. ;
Puder, Mark .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2018, 42 (01) :71-77
[3]   IS URSODEOXYCHOLIC ACID AN EFFECTIVE THERAPY FOR TOTAL PARENTERAL NUTRITION-RELATED LIVER-DISEASE [J].
BEAU, P ;
LABATLABOURDETTE, J ;
INGRAND, P ;
BEAUCHANT, M .
JOURNAL OF HEPATOLOGY, 1994, 20 (02) :240-244
[4]   Efficacy of Teduglutide for Parenteral Support Reduction in Patients with Short Bowel Syndrome: A Systematic Review and Meta-Analysis [J].
Bioletto, Fabio ;
D'Eusebio, Chiara ;
Merlo, Fabio Dario ;
Aimasso, Umberto ;
Ossola, Marta ;
Pellegrini, Marianna ;
Ponzo, Valentina ;
Chiarotto, Alessia ;
De Francesco, Antonella ;
Ghigo, Ezio ;
Bo, Simona .
NUTRIENTS, 2022, 14 (04)
[5]   Assessing Non-Invasive Liver Function in Patients with Intestinal Failure Receiving Total Parenteral Nutrition-Results from the Prospective PNLiver Trial [J].
Bluethner, Elisabeth ;
Pape, Ulrich-Frank ;
Stockmann, Martin ;
Karber, Mirjam ;
Maasberg, Sebastian ;
Pevny, Sophie ;
Gerlach-Runge, Undine ;
Pascher, Andreas ;
Pratschke, Johann ;
Tacke, Frank ;
Bednarsch, Jan .
NUTRIENTS, 2020, 12 (05)
[6]   Intravenous Fish Oil and Pediatric Intestinal Failure-Associated Liver Disease: Changes in Plasma Phytosterols, Cytokines, and Bile Acids and Erythrocyte Fatty Acids [J].
Calkins, Kara L. ;
DeBarber, Andrea ;
Steiner, Robert D. ;
Flores, Martiniano J. ;
Grogan, Tristan R. ;
Henning, Susanne M. ;
Reyen, Laurie ;
Venick, Robert S. .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2018, 42 (03) :633-641
[7]   To Wean or Not to Wean: The Role of Autologous Reconstructive Surgery in the Natural History of Pediatric Short Bowel Syndrome on Behalf of Italian Society for Gastroenterology, Hepatology and Nutrition (SIGENP) [J].
Capriati, Teresa ;
Mosca, Antonella ;
Alterio, Tommaso ;
Spagnuolo, Maria Immacolata ;
Gandullia, Paolo ;
Lezo, Antonella ;
Lionetti, Paolo ;
D'Antiga, Lorenzo ;
Fusaro, Fabio ;
Diamanti, Antonella .
NUTRIENTS, 2020, 12 (07) :1-15
[8]   Ursodeoxycholic acid (UDCA) therapy in very-low-birth-weight infants with parenteral nutrition-associated cholestasis [J].
Chen, CY ;
Tsao, PN ;
Chen, HL ;
Chou, HC ;
Hsieh, WS ;
Chang, MH .
JOURNAL OF PEDIATRICS, 2004, 145 (03) :317-321
[9]   Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition in children [J].
Colomb, V ;
Jobert-Giraud, A ;
Lacaille, F ;
Goulet, O ;
Fournet, JC ;
Ricour, C .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2000, 24 (06) :345-350
[10]  
Daniel Shawnee, 2021, J Pediatr Pharmacol Ther, V26, P258, DOI 10.5863/1551-6776-26.3.258