Effect of Glyprolines PGP, GP, and PG on Homeostasis of Gastric Mucosa in Rats with Experimental Ethanol-Induced Gastric Ulcers

被引：8

作者：

Falalyeyeva, T. M. ^{[2
]}

Samonina, G. E. ^{[1
]}

Beregovaya, T. V. ^{[2
]}

Andreeva, L. A. ^{[3
]}

Dvorshchenko, E. A. ^{[2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Human & Anim Physiol, Fac Biol, Moscow 117234, Russia

[2] TG Shevchenko Kiev State Univ, Dept Physiol & Pharmacol, Fac Biol, Kiev, Ukraine

[3] Russian Acad Sci, Inst Mol Genet, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 06期

关键词：

glyprolines; ethanol; gastric mucosa; lipid peroxidation; antioxidant enzymes;

D O I：

10.1007/s10517-010-1028-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The decrease in the severity of erosions and ulcer lesions after preventive treatment with PGP or PG correlated with a decrease in the content of lipid peroxidation products to a control level. Activities of SOD and catalase also returned to control values. GP produced the weakest effect on pro-and antioxidant state of the gastric mucosa. We concluded that the pronounced preventive effect of PGP and PG on the development of ethanol-induced erosions and ulcer lesions is largely determined by their antioxidant properties. Glyprolines can be considered as a promising means for prevention and treatment of stomach and duodenal ulcers.

引用

页码：699 / 701

页数：3

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