Novel m1 muscarinic agonists in treatment and delaying the progression of Alzheimer's disease: An unifying hypothesis

被引：15

作者：

Fisher, A ^{[1
]}

Brandeis, R ^{[1
]}

Haring, R ^{[1
]}

Eshhar, N ^{[1
]}

Heldman, E ^{[1
]}

Karton, Y ^{[1
]}

Eisenberg, O ^{[1
]}

Meshulam, H ^{[1
]}

Marciano, D ^{[1
]}

Bar-Ner, N ^{[1
]}

Pittel, Z ^{[1
]}

机构：

[1] Israel Inst Biol Res, IL-74100 Ness Ziona, Israel

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 5-6期

关键词：

AF series; m1; agonists; Alzheimer's disease;

D O I：

10.1016/S0928-4257(99)80001-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

M1 selective agonists from the AF series (e.g. AF102B, AF150(S)), via ml muscarinic receptors, activate distinct signal transductions, enhance amyloid precursors proteins secretion from transfected cells and primary cell cultures, show neurotrophic effects and are beneficial in a variety of animal models for Alzheimer's disease. Such mi agonists may be effective in the treatment and therapy of Alzheimer's disease. ((C) Elsevier, Paris).

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收藏

页码：337 / 340

页数：4

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