Cytotoxicity of phloroglucinol engineered silver (Ag) nanoparticles against MCF-7 breast cancer cell lines

被引：30
|
作者：
Kumar, Ponnuchamy [1 ]
Yuvakkumar, Rathinam [2 ]
Vijayakumar, Sekar [3 ]
Vaseeharan, Baskaralingam [3 ]
机构：
[1] Alagappa Univ, Food Chem & Mol Canc Biol Lab, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India
[2] Alagappa Univ, Dept Phys, Karaikkudi 630003, Tamil Nadu, India
[3] Alagappa Univ, Nanobiosci & Nanopharmacol Div, Biomat & Biotechnol Anim Hlth Lab, Dept Anim Hlth & Management, Sci Campus 6th Floor, Karaikkudi 630003, Tamil Nadu, India
来源：
MATERIALS CHEMISTRY AND PHYSICS | 2018年 / 220卷
关键词：
Phloroglucinol; Silver nanoparticles; Breast cancer cell lines; Dose-dependent manner; Marine bioactive compound; ENCAPSULATED STARCH BIOPOLYMER; ANTIOXIDANT; EXTRACT; BIOSYNTHESIS;
D O I：
10.1016/j.matchemphys.2018.08.074
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In the present study, phloroglucinol engineered silver (Ag) nanoparticles were prepared by a simple and green method. The results from the study revealed that the Ag nanoparticles are polydispersed, spherical in shape, crystalline in nature and encompass negative surface charge. Furthermore, the presence of phenolic OH group of phloroglucinol plays a major role in the formation and stabilization of Ag nanoparticles. In addition, the cytotoxic properties of phloroglucinol engineered silver (Ag) nanoparticles were assessed against MCF-7 breast cancer cell lines. Our results revealed that, Ag nanoparticles are effective in killing MCF-7 breast cancer cell lines in a dose-dependent manner. Overall, the study is obvious in delivering a marine bioactive compound, phloroglucinol in the form of inorganic nanomaterials with cytotoxic property.
引用
收藏
页码：402 / 408
页数：7
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