Characteristics of Donor-Specific Antibodies Associated With Antibody-Mediated Rejection in Lung Transplantation

被引：28

作者：

Roux, Antoine ^{[1
,2
,3
]}

Le Lan, Ines Bendib ^{[1
]}

Holifanjaniaina, Sonia ^{[4
]}

Thomas, Kimberly A. ^{[2
]}

Picard, CleMent ^{[1
]}

Grenet, Dominique ^{[1
]}

De Miranda, Sandra ^{[1
]}

Douvry, Benoit ^{[1
]}

Beaumont-Azuar, Laurence ^{[1
]}

Sage, Edouard ^{[3
,5
]}

Devaquet, Jerome ^{[6
]}

Cuquemelle, Elise ^{[7
]}

Le Guen, Morgan ^{[8
]}

Suberbielle, Caroline ^{[9
]}

Gautreau, Chantal ^{[9
]}

Stern, Marc ^{[1
]}

Rossetti, Maura ^{[2
]}

Hamid, Abdul Monem ^{[1
]}

Parquin, Francois ^{[6
]}

机构：

[1] Foch Hosp, Lung Transplantat Dept, Adult CF Ctr, Pneumol, Suresnes, France

[2] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA USA

[3] Univ Versailles St Quentin En Yvelines, Montigny Le Bretonneux, France

[4] Foch Hosp, Dept Pathol, Suresnes, France

[5] Foch Hosp, Dept Thorac Surg, Suresnes, France

[6] Foch Hosp, Intens Care Unit, Suresnes, France

[7] Foch Hosp, Thorac Intens Care Unit, Suresnes, France

[8] Foch Hosp, Dept Anesthesiol, Suresnes, France

[9] St Louis Hosp, AP HP, Lab Reg Histocompatibil, Paris, France

来源：

FRONTIERS IN MEDICINE | 2017年 / 4卷

关键词：

HLA; donor-specific antibodies; lung transplant; clinical outcome; antibody mediated rejection; BRONCHIOLITIS OBLITERANS SYNDROME; KIDNEY-TRANSPLANT; HLA ANTIBODIES; ALLOGRAFT DYSFUNCTION; RECIPIENTS; STRENGTH; FAILURE; HEART;

D O I：

10.3389/fmed.2017.00155

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) are frequently found in recipients after lung transplantation (LT), the characteristics of DSA which influence antibody-mediated rejection (AMR) in LT are not fully defined. We retrospectively analyzed 206 consecutive LT patients of our center (2010-2013). DSAs were detected by using luminex single antigen beads assay and mean fluorescence intensity was assessed. Within the study population, 105 patients had positive DSA. Patients with and without AMR (AMRPos, n = 22, and AMRNeg, n = 83, respectively) were compared. AMRPos patients had significantly greater frequencies of anti-HLA DQ DSA (DQ DSA) than AMRNeg patients (95 vs 58%, respectively, p < 0.0001). Compared to AMRNeg patients, AMRPos patients had higher DQ DSA sum MFI [7,332 (2,067-10,213) vs 681 (0-1,887), p < 0.0001]. DQ DSA when associated with AMR, had more frequent graft loss and chronic lung allograft dysfunction (CLAD). These data suggest (i) that DSA characteristics clearly differ between AMRPos and AMRNeg patients and (ii) the deleterious impact of DQ DSA on clinical outcome.

引用

页数：10

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