The Controversial Role of IL-33 in Lung Cancer

被引：14

作者：

Yang, Keshan ^{[1
]}

Tian, Cheng ^{[1
]}

Zhang, Chengliang ^{[2
]}

Xiang, Ming ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Dept Pharmacol, Wuhan, Peoples R China

[2] Huazhong Sci andTechnol Univ, Dept Pharm Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

IL-33; immune regulation; pulmonary fibrosis; lung cancer; dual regulation; PROPHYLACTIC CRANIAL IRRADIATION; TYROSINE KINASE INHIBITORS; ST2; GENE-PRODUCT; T-CELLS; VARIANT FORM; TUMOR-GROWTH; NK CELLS; C-MYC; EXPRESSION; CYTOKINE;

D O I：

10.3389/fimmu.2022.897356

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-33 (IL-33) belongs to the interleukin-1 (IL-1) family, and its structure is similar to IL-18. When cells are damaged or undergo necrosis, mature form of IL-33 is secreted as a cytokine, which can activate the immune system and provide danger signals. The IL-33/ST2 signaling pathway is composed of IL-33, suppression of tumorigenicity 2 (ST2), and IL-1 receptor accessory protein (IL-1RAcP). IL-33 has been reported to be strongly associated with lung cancer progression, and can exhibit opposite effects on lung cancer under different conditions. In this review, we have summarized the structure and basic functions of IL-33, its possible function in immune regulation, and its role in pulmonary fibrosis as well as in lung cancer. We have highlighted the dual regulation of IL-33 in lung cancer and proposed potential lung cancer treatment regimens, especially new immunotherapies, based on its mechanism of action.

引用

页数：11

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