Effects of age on dopamine D2 receptor availability in striatal subdivisions: A high-resolution positron emission tomography study

被引：20

作者：

Kim, Jong-Hoon ^{[2
]}

Son, Young-Don ^{[1
]}

Kim, Hang-Keun ^{[1
]}

Lee, Sang-Yoon ^{[1
]}

Cho, Seo-Eun ^{[2
]}

Kim, Young-Bo ^{[1
,3
]}

Cho, Zang-Hee ^{[1
]}

机构：

[1] Gachon Univ Med & Sci, Neurosci Res Inst, Inchon 405760, South Korea

[2] Gachon Univ Med & Sci, Gil Hosp, Dept Psychiat, Inchon 405760, South Korea

[3] Gachon Univ Med & Sci, Gil Hosp, Dept Neurosurg, Inchon 405760, South Korea

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2011年 / 21卷 / 12期

关键词：

Age; Dopamine; D-2; receptor; Striatal subdivisions; Positron emission tomography; Raclopride; HUMAN BRAIN; BINDING; DECLINE; QUANTIFICATION; TRANSMISSION; ORGANIZATION; ASSOCIATION; IMPAIRMENT; SYSTEM;

D O I：

10.1016/j.euroneuro.2011.03.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of the present study was to examine the relationship between age and dopamine D-2 receptor availability in striatal subdivisions of young and middle-aged healthy subjects using high-resolution positron emission tomography (PET) with [C-11]raclopride to better characterize the nature of age-related decrements in striatal D-2 receptor availability. Twenty-four healthy volunteers completed 3-Tesla magnetic resonance imaging and high-resolution [C-11]raclopride PET scans. The analyses using linear and exponential models revealed that age had a significant negative correlation with D-2 receptor availability in the post-commissural putamen (postPU) and that D-2 receptor binding in the postPU decreased significantly more with age than in the ventral striatum, suggesting subregional differences in age-related changes in D-2 receptor binding. The postPU, which belongs to the sensorimotor striatum, may be particularly vulnerable to the effects of age in young and middle-aged subjects. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：885 / 891

页数：7

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