Identification of potential multitarget antimalarial drugs

被引:19
作者
Jenwitheesuk, E [1 ]
Samudrala, R [1 ]
机构
[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2005年 / 294卷 / 12期
关键词
D O I
10.1001/jama.294.12.1490
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1490 / 1491
页数:2
相关论文
共 9 条
[1]   Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum [J].
Asojo, OA ;
Gulnik, SV ;
Afonina, E ;
Yu, B ;
Ellman, JA ;
Haque, TS ;
Silva, AM .
JOURNAL OF MOLECULAR BIOLOGY, 2003, 327 (01) :173-181
[2]   Drug therapy: Effectiveness of antimalarial drugs [J].
Baird, JK .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (15) :1565-1577
[3]   Distribution of proline-rich (PxxP) motifs in distinct proteomes: functional and therapeutic implications for malaria and tuberculosis [J].
Chandra, BR ;
Gowthaman, R ;
Akhouri, RR ;
Gupta, D ;
Sharma, A .
PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (02) :175-182
[4]  
*CHEMBANK, LIG INF SUBS
[5]   The efficiency of multi-target drugs: the network approach might help drug design [J].
Csermely, P ;
Agoston, V ;
Pongor, S .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2005, 26 (04) :178-182
[6]  
Fungladda W, 1998, Bull World Health Organ, V76 Suppl 1, P59
[7]  
Heppner DG, 2005, VACCINE, V23, P2243, DOI 10.1016/j.vaccine.2005.01.042
[8]   MALARIA VACCINES - MULTIPLE TARGETS [J].
NUSSENZWEIG, RS ;
LONG, CA .
SCIENCE, 1994, 265 (5177) :1381-1383
[9]   Insights into antifolate resistance from malarial DHFR-TS structures [J].
Yuvaniyama, J ;
Chitnumsub, P ;
Kamchonwongpaisan, S ;
Vanichtanankul, J ;
Sirawaraporn, W ;
Taylor, P ;
Walkinshaw, MD ;
Yuthavong, Y .
NATURE STRUCTURAL BIOLOGY, 2003, 10 (05) :357-365