Normal levels of serum IGF-I: determinants and validity of current reference ranges

被引：60

作者：

Brabant, G. ^{[1
]}

Wallaschofski, H. ^{[2
]}

机构：

[1] Christie Hosp NHS Trust, Dept Endocrinol, Manchester M20 4BX, Lancs, England

[2] Ernst Moritz Arndt Univ Greifswald, Dept Gastroenterol Endocrinol & Nutr, Greifswald, Germany

来源：

PITUITARY | 2007年 / 10卷 / 02期

关键词：

IGF-I; gender; age; genetics; nutrition; disease dependency; GROWTH-FACTOR-I; FACTOR-BINDING-PROTEIN; CARDIOVASCULAR-DISEASE; REFERENCE VALUES; INSULIN; HORMONE; RISK; ADULTS; AGE; ADOLESCENCE;

D O I：

10.1007/s11102-007-0035-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over-or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I.

引用

页码：129 / 133

页数：5

共 38 条

[1] PLASMA INSULIN-LIKE GROWTH FACTOR-I/SOMATOMEDIN-C IN ACROMEGALY - CORRELATION WITH THE DEGREE OF GROWTH-HORMONE HYPERSECRETION [J].

BARKAN, AL ;

BEITINS, IZ ;

KELCH, RP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (01) :69-73

[2] Serum IGF-I and IGFBP-3 levels of Turkish children during childhood and adolescence: Establishment of reference ranges with emphasis on puberty [J].

Bereket, A ;

Turan, S ;

Omar, A ;

Berber, M .

HORMONE RESEARCH, 2006, 65 (02) :96-105

[3] GROWTH-HORMONE RESISTANCE AND INHIBITION OF SOMATOMEDIN ACTIVITY BY EXCESS OF INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN IN UREMIA [J].

BLUM, WF ;

RANKE, MB ;

KIETZMANN, K ;

TONSHOFF, B ;

MEHLS, O .

PEDIATRIC NEPHROLOGY, 1991, 5 (04) :539-544

[4]

Borofsky ND, 2002, CLIN CHEM, V48, P2248

[5] Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system:: Results from a multicenter study [J].

Brabant, G ;

von zur Mühlen, A ;

Wüster, C ;

Ranke, MB ;

Kratzsch, J ;

Kiess, W ;

Ketelslegers, JM ;

Wilhelmsen, L ;

Hulthén, L ;

Saller, B ;

Mattsson, A ;

Wilde, J ;

Schemer, R ;

Kann, P .

HORMONE RESEARCH, 2003, 60 (02) :53-60

[6] Insulin-like growth factor-I: marker for diagnosis of acromegaly and monitoring the efficacy of treatment [J].

Brabant, G .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2003, 148 :S15-S20

[7] REGULATION OF MATERNAL IGF-I BY PLACENTAL GH IN NORMAL AND ABNORMAL HUMAN PREGNANCIES [J].

CAUFRIEZ, A ;

FRANKENNE, F ;

HENNEN, G ;

COPINSCHI, G .

AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (04) :E572-E577

[8] Changes in bioactive IGF-I and IGF-binding protein-1 during an oral glucose tolerance test in patients with liver cirrhosis [J].

Chen, Jian-Wen ;

Nielsen, Michael F. ;

Caumo, Andrea ;

Vilstrup, Hendrik ;

Christiansen, Jens Sandahl .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2006, 155 (02) :285-292

[9]

deBoer H, 1996, INT J OBESITY, V20, P580

[10] Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) [J].

Elmlinger, MW ;

Kühnel, W ;

Weber, MM ;

Ranke, MB .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2004, 42 (06) :654-664

← 1 2 3 4 →