OUTCOMES AFTER DEFINITIVE TREATMENT FOR CUTANEOUS ANGIOSARCOMA OF THE FACE AND SCALP

被引：137

作者：

Guadagnolo, B. Ashleigh ^{[1
]}

Zagars, Gunar K. ^{[1
]}

Araujo, Dejka ^{[2
]}

Ravi, Vinod ^{[2
]}

Shellenberger, Thomas D. ^{[3
]}

Sturgis, Erich M. ^{[4
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Div Radiat Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Med Oncol, Houston, TX 77030 USA

[3] MD Anderson Canc Ctr Orlando, Thorac Head & Neck Dept, Orlando, FL USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 05期

关键词：

cutaneous; angiosarcoma; scalp; radiation therapy; surgery; local control; HEAD; NECK; RADIOTHERAPY; PACLITAXEL;

D O I：

10.1002/hed.21513

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The aim of the present analysis was to retrospectively evaluate outcomes in patients with cutaneous angiosarcoma of the face/scalp treated curatively with surgery, radiation therapy (RT), or a combination of surgery and RT. Methods. In all, 70 patients with nonmetastatic angiosarcoma underwent surgery, RT, or combined-modality therapy. Of these, 20 patients (29%) were treated with surgery alone, 27 patients (39%) with RT alone, and 23 patients (33%) with combined-modality therapy; 44 patients received chemotherapy, either neoadjuvantly or adjuvantly or both. Results. Median follow-up was 2.1 years. The overall survival (OS) rate was 43% at 5 years, and disease-specific survival (DSS) was 46% at 5 years. Tumor size > 5 cm and satellitosis were prognostic for inferior OS and DSS. Combined-modality therapy (vs surgery alone or RT alone) was associated with improved OS, DSS, and local control. Conclusions. Primary local therapy with combined-modality therapy was associated with improved local control, OS, and DSS for patients with angiosarcoma of the face/scalp. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 661-667, 2011

引用

页码：661 / 667

页数：7

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