A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study

被引：35

作者：

Chajes, V. ^{[1
]}

Assi, N. ^{[1
]}

Biessy, C. ^{[1
]}

Ferrari, P. ^{[1
]}

Rinaldi, S. ^{[1
]}

Slimani, N. ^{[1
]}

Lenoir, G. M. ^{[2
]}

Baglietto, L. ^{[2
,3
]}

His, M. ^{[2
,3
]}

Boutron-Ruault, M. C. ^{[2
,3
]}

Trichopoulou, A. ^{[4
,5
]}

Lagiou, P. ^{[4
,5
,6
]}

Katsoulis, M. ^{[4
]}

Kaaks, R. ^{[7
]}

Kuehn, T. ^{[7
]}

Panico, S. ^{[8
]}

Pala, V. ^{[9
]}

Masala, G. ^{[10
]}

Bueno-de-Mesquita, H. B. ^{[11
,12
,13
]}

Peeters, P. H. ^{[14
]}

van Gils, C. ^{[14
]}

Hjartaker, A. ^{[15
]}

Olsen, K. Standahl ^{[16
]}

Barnung, R. Borgund ^{[16
]}

Barricarte, A. ^{[17
,18
,19
]}

Redondo-Sanchez, D. ^{[19
,20
,21
]}

Menendez, V. ^{[22
]}

Amiano, P. ^{[19
,23
]}

Wennberg, M. ^{[24
]}

Key, T. ^{[25
]}

Khaw, K. T. ^{[26
]}

Merritt, M. A. ^{[12
]}

Riboli, E. ^{[12
]}

Gunter, M. J. ^{[1
]}

Romieu, I. ^{[1
]}

机构：

[1] Int Agcy Res Canc, Nutr & Metab Sect, Lyon, France

[2] Inst Gustave Roussy, Villejuif, France

[3] Univ Paris Sud, Univ Paris Saclay, UVSQ, CESP,INSERM, Villejuif, France

[4] Hellen Hlth Fdn, Athens, Greece

[5] Univ Athens, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth,Med Sch, Athens, Greece

[6] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[7] German Canc Res Ctr, Heidelberg, Germany

[8] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[9] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[10] Canc Res & Prevent Inst ISPO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[11] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, Bilthoven, Netherlands

[12] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[13] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia

[14] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[15] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway

[16] Univ Tromso UiT, Dept Community Med, Tromso, Norway

[17] Navarra Publ Hlth Inst, Navarra, Spain

[18] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[19] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain

[20] Hosp Univ Granada, Inst Invest Biosanitaria Ibs Granada, Escuela Andaluza Salud Publ, Granada, Spain

[21] Univ Granada, Granada, Spain

[22] Publ Hlth Directorate, Asturias, Spain

[23] Dept Hlth, Publ Hlth Div Gipuzkoa, San Sebastian, Basque Region, Spain

[24] Umea Univ, Publ Hlth & Clin Med Nutr Res, Umea, Sweden

[25] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[26] Univ Cambridge, Sch Clin Med, Cambridge, England

来源：

ANNALS OF ONCOLOGY | 2017年 / 28卷 / 11期

基金：

英国医学研究理事会;

关键词：

fatty acids; biomarkers; breast cancer; epidemiology; EPIC; METAANALYSIS; LIPOGENESIS; RATIO; DIET;

D O I：

10.1093/annonc/mdx482

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intakes of specific fatty acids have been postulated to impact breast cancer risk but epidemiological data based on dietary questionnaires remain conflicting. We assessed the association between plasma phospholipid fatty acids and breast cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Sixty fatty acids were measured by gas chromatography in pre-diagnostic plasma phospholipids from 2982 incident breast cancer cases matched to 2982 controls. Conditional logistic regression models were used to estimate relative risk of breast cancer by fatty acid level. The false discovery rate (q values) was computed to control for multiple comparisons. Subgroup analyses were carried out by estrogen receptor (ER) and progesterone receptor expression in the tumours. A high level of palmitoleic acid [odds ratio (OR) for the highest quartile compared with the lowest OR (Q4-Q1) 1.37; 95% confidence interval (CI), 1.14-1.64; P for trend = 0.0001, q value = 0.004] as well as a high desaturation index (DI16) (16:1n-7/16:0) [OR (Q4-Q1), 1.28; 95% C, 1.07-1.54; P for trend = 0.002, q value = 0.037], as biomarkers of de novo lipogenesis, were significantly associated with increased risk of breast cancer. Levels of industrial trans-fatty acids were positively associated with ER-negative tumours [OR for the highest tertile compared with the lowest (T3-T1)=2.01; 95% CI, 1.03-3.90; P for trend = 0.047], whereas no association was found for ER-positive tumours (P-heterogeneity =0.01). No significant association was found between n-3 polyunsaturated fatty acids and breast cancer risk, overall or by hormonal receptor. These findings suggest that increased de novo lipogenesis, acting through increased synthesis of palmitoleic acid, could be a relevant metabolic pathway for breast tumourigenesis. Dietary trans-fatty acids derived from industrial processes may specifically increase ER-negative breast cancer risk.

引用

页码：2836 / 2842

页数：7

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