Thromboinflammation as a Driver of Venous Thromboembolism

被引：6

作者：

Gauchel, Nadine ^{[1
]}

Krauel, Krystin ^{[1
]}

Hamad, Muataz Ali ^{[1
]}

Bode, Christoph ^{[1
]}

Duerschmied, Daniel ^{[1
]}

机构：

[1] Univ Freiburg, Fac Med, Univ Heart Ctr Freiburg Bad Krozingen, Dept Cardiol & Angiol 1, Hugstetter Str 55, Freiburg 79106, Germany

来源：

HAMOSTASEOLOGIE | 2021年 / 41卷 / 06期

关键词：

thromboinflammation; immunothrombosis; innate immunity; venous thromboembolism; COVID-19; DEEP-VEIN THROMBOSIS; COMPLEMENT; COVID-19; ACTIVATION; NEUTROPHILS; PLATELETS; ASPIRIN;

D O I：

10.1055/a-1661-0257

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombus formation has been identified as an integral part in innate immunity, termed immunothrombosis. Activation of host defense systems is known to result in a procoagulant environment. In this system, cellular players as well as soluble mediators interact with each other and their dysregulation can lead to the pathological process of thromboinflammation. These mechanisms have been under intensified investigation during the COVID-19 pandemic. In this review, we focus on the underlying mechanisms leading to thromboinflammation as one trigger of venous thromboembolism.

引用

页码：428 / 432

页数：5

共 62 条

[1] The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management [J].

Abou-Ismail, Mouhamed Yazan ;

Diamond, Akiva ;

Kapoor, Sargam ;

Arafah, Yasmin ;

Nayak, Lalitha .

THROMBOSIS RESEARCH, 2020, 194 :101-115

[2] Aspirin for Preventing the Recurrence of Venous Thromboembolism [J].

Becattini, Cecilia ;

Agnelli, Giancarlo ;

Schenone, Alessandro ;

Eichinger, Sabine ;

Bucherini, Eugenio ;

Silingardi, Mauro ;

Bianchi, Marina ;

Moia, Marco ;

Ageno, Walter ;

Vandelli, Maria Rita ;

Grandone, Elvira ;

Prandoni, Paolo .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (21) :1959-1967

[3] COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow [J].

Bikdeli, Behnood ;

Madhavan, Mahesh V. ;

Jimenez, David ;

Chuich, Taylor ;

Dreyfus, Isaac ;

Driggin, Elissa ;

Der Nigoghossian, Caroline ;

Ageno, Walter ;

Madjid, Mohammad ;

Guo, Yutao ;

Tang, Liang V. ;

Hu, Yu ;

Giri, Jay ;

Cushman, Mary ;

Quere, Isabelle ;

Dimakakos, Evangelos P. ;

Gibson, C. Michael ;

Lippi, Giuseppe ;

Favaloro, Emmanuel J. ;

Fareed, Jawed ;

Caprini, Joseph A. ;

Tafur, Alfonso J. ;

Burton, John R. ;

Francese, Dominic P. ;

Wang, Elizabeth Y. ;

Falanga, Anna ;

McLintock, Claire ;

Hunt, Beverley J. ;

Spyropoulos, Alex C. ;

Barnes, Geoffrey D. ;

Eikelboom, John W. ;

Weinberg, Ido ;

Schulman, Sam ;

Carrier, Marc ;

Piazza, Gregory ;

Beckman, Joshua A. ;

Steg, Gabriel ;

Stone, Gregg W. ;

Rosenkranz, Stephan ;

Goldhaber, Samuel Z. ;

Parikh, Sahil A. ;

Monreal, Manuel ;

Krumholz, Harlan M. ;

Konstantinides, Stavros V. ;

Weitz, Jeffrey I. ;

Lip, Gregory Y. H. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 75 (23) :2950-2973

[4] Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19 [J].

Bonaventura, Aldo ;

Vecchie, Alessandra ;

Dagna, Lorenzo ;

Martinod, Kimberly ;

Dixon, Dave L. ;

Van Tassell, Benjamin W. ;

Dentali, Francesco ;

Montecucco, Fabrizio ;

Massberg, Steffen ;

Levi, Marcel ;

Abbate, Antonio .

NATURE REVIEWS IMMUNOLOGY, 2021, 21 (05) :319-329

[5]

Borghi MO, 2020, FRONT IMMUNOL, V11, DOI [10.1101/2020.06.17.20134114, 10.3389/fimmu.2020.584241]

[6]

Borish Larry C., 2003, Journal of Allergy and Clinical Immunology, V111, pS460

[7] Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism [J].

Brighton, Timothy A. ;

Eikelboom, John W. ;

Mann, Kristy ;

Biostat, M. ;

Mister, Rebecca ;

Gallus, Alexander ;

Ockelford, Paul ;

Gibbs, Harry ;

Hague, Wendy ;

Xavier, Denis ;

Diaz, Rafael ;

Kirby, Adrienne ;

Simes, John .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (21) :1979-1987

[8] Neutrophil extracellular traps promote deep vein thrombosis in mice [J].

Brill, A. ;

Fuchs, T. A. ;

Savchenko, A. S. ;

Thomas, G. M. ;

Martinod, K. ;

De Meyer, S. F. ;

Bhandari, A. A. ;

Wagner, D. D. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (01) :136-144

[9] von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models [J].

Brill, Alexander ;

Fuchs, Tobias A. ;

Chauhan, Anil K. ;

Yang, Janie J. ;

De Meyer, Simon F. ;

Koellnberger, Maria ;

Wakefield, Thomas W. ;

Laemmle, Bernhard ;

Massberg, Steffen ;

Wagner, Denisa D. .

BLOOD, 2011, 117 (04) :1400-1407

[10] Platelets: New Bricks in the Building of Neutrophil Extracellular Traps [J].

Carestia, Agostina ;

Kaufman, Tomas ;

Schattner, Mirta .

FRONTIERS IN IMMUNOLOGY, 2016, 7 :1-9

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