Transcriptional intermediary factor 1 (TIF1) and anti-TIF1γ antibody-positive dermatomyositis

被引：20

作者：

Kotobuki, Yorihisa ^{[1
]}

Tonomura, Kyoko ^{[1
]}

Fujimoto, Manabu ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Dermatol, Course Integrated Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

IMMUNOLOGICAL MEDICINE | 2021年 / 44卷 / 01期

关键词：

TIF1; anti-TIF1 gamma antibody; dermatomyositis; cancer-associated myositis; TGF-BETA; AUTOANTIBODY PHENOTYPES; SIGNALING PATHWAY; TIF1-GAMMA; PROTEIN; ASSOCIATION; FEATURES; DISEASE; SMAD4;

D O I：

10.1080/25785826.2020.1791402

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, great advancements have been made towards understanding the mechanisms underlying dermatomyositis (DM). Many novel autoantibodies, such as anti-MDA5, anti-TIF1 gamma, anti-NXP2, and anti-SAE, have been reported to be involved in DM. DM is now classified based on these myositis-specific autoantibodies. Anti-TIF1 gamma antibodies are closely associated with juvenile DM and adult cancer-associated DM. Anti-TIF1 gamma antibody-positive DM tends to present severe cutaneous manifestations, mild myositis, and dysphagia. TIF1 gamma (also known as TRIM33) plays a role in transcriptional elongation, DNA repair, differentiation of cells, embryonic development, and mitosis. Moreover, TIF1 gamma has been shown to suppress various tumors via the TGF-beta/Smad and the Wnt/beta-Catenin signaling pathways. In this review, we explore the relationship between TIF1 gamma, cancer, and DM. We also discuss the pathogenesis of anti-TIF1 gamma antibody-positive DM.

引用

收藏

页码：23 / 29

页数：7

相关论文

共 46 条

[1] Antinuclear Matrix Protein 2 Autoantibodies and Edema, Muscle Disease, and Malignancy Risk in Dermatomyositis Patients [J].

Albayda, Jemima ;

Pinal-Fernandez, Iago ;

Huang, Wilson ;

Parks, Cassie ;

Paik, Julie ;

Casciola-Rosen, Livia ;

Danoff, Sonye K. ;

Johnson, Cheilonda ;

Christopher-Stine, Lisa ;

Mammen, Andrew L. .

ARTHRITIS CARE & RESEARCH, 2017, 69 (11) :1771-1776

[2] New tricks for an old fox: Impact of TGFβ on the DNA damage response and genomic stability [J].

Barcellos-Hoff, Mary Helen ;

Cucinotta, Francis A. .

SCIENCE SIGNALING, 2014, 7 (341)

[3] Myositis-specific autoantibodies: an important tool to support diagnosis of myositis [J].

Betteridge, Z. ;

McHugh, N. .

JOURNAL OF INTERNAL MEDICINE, 2016, 280 (01) :8-23

[4] DnA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance [J].

Centurione, Lucia ;

Aiello, Francesca B. .

FRONTIERS IN ONCOLOGY, 2016, 6

[5] Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition [J].

Derynck, Rik ;

Muthusamy, Baby Periyanayaki ;

Saeteurn, Koy Y. .

CURRENT OPINION IN CELL BIOLOGY, 2014, 31 :56-66

[6] Distinctive cutaneous and systemic features associated with antitranscriptional intermediary factor-1γ antibodies in adults with dermatomyositis [J].

Fiorentino, David F. ;

Kuo, Karen ;

Chung, Lorinda ;

Zaba, Lisa ;

Li, Shufeng ;

Casciola-Rosen, Livia .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015, 72 (03) :449-455

[7] Recent advances in dermatomyositis-specific autoantibodies [J].

Fujimoto, Manabu ;

Watanabe, Rei ;

Ishitsuka, Yosuke ;

Okiyama, Naoko .

CURRENT OPINION IN RHEUMATOLOGY, 2016, 28 (06) :636-644

[8] Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins [J].

Fujimoto, Manabu ;

Hamaguchi, Yasuhito ;

Kaji, Kenzo ;

Matsushita, Takashi ;

Ichimura, Yuki ;

Kodera, Masanari ;

Ishiguro, Naoko ;

Ueda-Hayakawa, Ikuko ;

Asano, Yoshihide ;

Ogawa, Fumihide ;

Fujikawa, Keita ;

Miyagi, Takuya ;

Mabuchi, Eriko ;

Hirose, Kenji ;

Akimoto, Narihiro ;

Hatta, Naohito ;

Tsutsui, Kiyohiro ;

Higashi, Akira ;

Igarashi, Atsuyuki ;

Seishima, Mariko ;

Hasegawa, Minoru ;

Takehara, Kazuhiko .

ARTHRITIS AND RHEUMATISM, 2012, 64 (02) :513-522

[9] Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication of dermatomyositis [J].

Gono, Takahisa ;

Kawaguchi, Yasushi ;

Ozeki, Eri ;

Ota, Yuko ;

Satoh, Takashi ;

Kuwana, Masataka ;

Hara, Masako ;

Yamanaka, Hisashi .

MODERN RHEUMATOLOGY, 2011, 21 (02) :223-227

[10] Clinical associations of autoantibodies to a p155/140 kDa doublet protein in juvenile dermatomyositis [J].

Gunawardena, H. ;

Wedderburn, L. R. ;

North, J. ;

Betteridge, Z. ;

Dunphy, J. ;

Chinoy, H. ;

Davidson, J. E. ;

Cooper, R. G. ;

McHugh, N. J. .

RHEUMATOLOGY, 2008, 47 (03) :324-328

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