The effect of bariatric surgery on breast cancer incidence and characteristics: A meta-analysis and systematic review

被引：36
作者：
Lovrics, O. [1 ]
Butt, J. [1 ]
Lee, Y. [2 ]
Lovrics, P. [2 ]
Boudreau, V [2 ,3 ]
Anvari, M. [2 ,3 ]
Hong, D. [2 ,3 ]
Doumouras, A. G. [2 ,3 ]
机构：
[1] McMaster Univ, Fac Med, 1280 Main St W, Hamilton, ON, Canada
[2] McMaster Univ, Div Gen Surg, 1280 Main St W, Hamilton, ON, Canada
[3] St Josephs Healthcare Hamilton, Ctr Minimal Access Surg CMAS, 50 Charlton Ave E, Hamilton, ON, Canada
来源：
AMERICAN JOURNAL OF SURGERY | 2021年 / 222卷 / 04期
关键词：
Bariatric surgery; Breast cancer; Risk reduction; Obesity-related cancer; BODY-MASS INDEX; PHYSICAL-ACTIVITY; OBESITY SURGERY; RISK; WEIGHT; OVERWEIGHT; BMI;
D O I：
10.1016/j.amjsurg.2021.03.016
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background: Obesity is a major risk factor for breast cancer. This study examines whether bariatric surgery affects breast cancer incidence in women with obesity compared to BMI-matched controls. Methods: EMBASE, MEDLINE, Web of Science, and CINAHL were searched. Primary studies on female breast cancer incidence after bariatric surgery were eligible. Results: 11 studies were included (n = 1,106,939). The rate of cancer diagnosis was lower in the surgical group (0.54%) compared to control (0.84%; risk ratio (RR) 0.50, 95%CI 0.37-0.67, I-2 = 88%). The results were robust to sensitivity analyses for patient age and study size. Bariatric surgery was associated with increased risk of stage I cancer (RR 1.23, 95%CI 1.06-1.44) and reduced risk of stage III or IV cancer (RR 0.50, 95%CI 0.28-0.88). Hormone receptor characteristics were not affected. Conclusions: Bariatric surgery is associated with reduced incidence and earlier stage at diagnosis of breast cancer in women with obesity compared to BMI-matched controls. (c) 2021 Elsevier Inc. All rights reserved.
引用
收藏
页码：715 / 722
页数：8
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