Combinatorial biocatalysis: taking the lead from Nature

被引：41

作者：

Altreuter, DH ^{[1
]}

Clark, DS ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem Engn, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0958-1669(99)80022-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Combinatorial biocatalysis is an emerging technology in the field of drug discovery. The biocatalytic approach to combinatorial chemistry uses enzymatic, chemoenzymatic, and microbial transformations to generate libraries from lead compounds. Important recent advances in combinatorial biocatalysis include iterative derivatization of small molecules and complex natural products, regioselectively controlled libraries, novel one-pot library syntheses, process automation, and biocalalyst enhancements.

引用

页码：130 / 136

页数：7

共 26 条

[1] The utility of enzymes in generating molecular diversity. Lipase mediated amidation of polybenzyl esters [J].

Adamczyk, M ;

Gebler, JC ;

Grote, J .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (08) :1027-1030

[2] Design by directed evolution [J].

Arnold, FH .

ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (03) :125-131

[3] Enzymatic synthesis of sialyl-Lewis-libraries with two nonnatural monosaccharide units [J].

Baisch, G ;

Öhrlein, R ;

Streiff, M ;

Kolbinger, F .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (07) :755-758

[4]

Bedell BA, 1998, BIOTECHNOL BIOENG, V58, P654, DOI 10.1002/(SICI)1097-0290(19980620)58:6<654::AID-BIT12>3.0.CO

[5]

2-7

[6] The evolution of biotransformation technologies [J].

Dordick, JS ;

Khmelnitsky, YL ;

Sergeeva, MV .

CURRENT OPINION IN MICROBIOLOGY, 1998, 1 (03) :311-318

[7] Synthesis of water-soluble paclitaxel derivatives by enzymatic acylation [J].

Khmelnitsky, YL ;

Budde, C ;

Arnold, JM ;

Usyatinsky, A ;

Clark, DS ;

Dordick, JS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (47) :11554-11555

[8]

KHMELNITSKY YL, 1996, ACS SYM SER, P144

[9] Directed evolution of enzyme catalysts [J].

Kuchner, O ;

Arnold, FH .

TRENDS IN BIOTECHNOLOGY, 1997, 15 (12) :523-530

[10] Combinatorial biocatalysis: a natural approach to drug discovery [J].

Michels, PC ;

Khmelnitsky, YL ;

Dordick, JS ;

Clark, DS .

TRENDS IN BIOTECHNOLOGY, 1998, 16 (05) :210-215

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